Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus

An increasing number of studies show that bisphenol A (BPA) can cause lipid metabolism disorder. However, few studies focused on the effect of BPA on lipid transport. Apolipoprotein E (ApoE) plays important roles in triglyceride (TG) transportation. Our previous study found that ApoE was a sensitive...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yingying Zhang, Zhu Zhu, Qiao Liu, Meng Zhang, Hui Yang, Wenzhi Wei
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bisphenol A Lipid metabolism Apolipoprotein E Liver Triglyceride Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/cd04d64e5af14d61843ecfef588218b4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd04d64e5af14d61843ecfef588218b4
record_format	dspace
spelling	oai:doaj.org-article:cd04d64e5af14d61843ecfef588218b42021-12-04T04:32:03ZBisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus0147-651310.1016/j.ecoenv.2021.113041https://doaj.org/article/cd04d64e5af14d61843ecfef588218b42021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011532https://doaj.org/toc/0147-6513An increasing number of studies show that bisphenol A (BPA) can cause lipid metabolism disorder. However, few studies focused on the effect of BPA on lipid transport. Apolipoprotein E (ApoE) plays important roles in triglyceride (TG) transportation. Our previous study found that ApoE was a sensitive gene in response to BPA exposure in male rare minnow. To investigate the effect and mechanism of BPA on hepatic ApoE, adult male rare minnow Gobiocypris rarus were exposed to environmentally relevant concentrations of BPA (15 μg/L) for 1, 3 and 5 weeks. Results showed that BPA inhibited ApoE expression at week 1 and 5, while induced its expression at week 3. A positive estrogen-related receptor gamma (Esrrg) response element was identified in the promoter region of ApoE. The change of the Esrrg recruitment was consistent with ApoE mRNA expression. Moreover, the methylation status of the CpG sites near and on the Esrrg binding sites changed opposite to the ApoE mRNA level, which may be the main cause for the change in Esrrg recruitment. The expression of ApoE protein was significantly enhanced following long-term BPA exposure. Consistently, the TG accumulation was significantly increased in the plasma. The present study demonstrates that BPA could affect rare minnow ApoE expression, which is probably one of the ways for BPA disturbing fish lipid metabolism.Yingying ZhangZhu ZhuQiao LiuMeng ZhangHui YangWenzhi WeiElsevierarticleBisphenol ALipid metabolismApolipoprotein ELiverTriglycerideEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113041- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bisphenol A Lipid metabolism Apolipoprotein E Liver Triglyceride Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Bisphenol A Lipid metabolism Apolipoprotein E Liver Triglyceride Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yingying Zhang Zhu Zhu Qiao Liu Meng Zhang Hui Yang Wenzhi Wei Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
description	An increasing number of studies show that bisphenol A (BPA) can cause lipid metabolism disorder. However, few studies focused on the effect of BPA on lipid transport. Apolipoprotein E (ApoE) plays important roles in triglyceride (TG) transportation. Our previous study found that ApoE was a sensitive gene in response to BPA exposure in male rare minnow. To investigate the effect and mechanism of BPA on hepatic ApoE, adult male rare minnow Gobiocypris rarus were exposed to environmentally relevant concentrations of BPA (15 μg/L) for 1, 3 and 5 weeks. Results showed that BPA inhibited ApoE expression at week 1 and 5, while induced its expression at week 3. A positive estrogen-related receptor gamma (Esrrg) response element was identified in the promoter region of ApoE. The change of the Esrrg recruitment was consistent with ApoE mRNA expression. Moreover, the methylation status of the CpG sites near and on the Esrrg binding sites changed opposite to the ApoE mRNA level, which may be the main cause for the change in Esrrg recruitment. The expression of ApoE protein was significantly enhanced following long-term BPA exposure. Consistently, the TG accumulation was significantly increased in the plasma. The present study demonstrates that BPA could affect rare minnow ApoE expression, which is probably one of the ways for BPA disturbing fish lipid metabolism.
format	article
author	Yingying Zhang Zhu Zhu Qiao Liu Meng Zhang Hui Yang Wenzhi Wei
author_facet	Yingying Zhang Zhu Zhu Qiao Liu Meng Zhang Hui Yang Wenzhi Wei
author_sort	Yingying Zhang
title	Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
title_short	Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
title_full	Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
title_fullStr	Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
title_full_unstemmed	Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus
title_sort	bisphenol a disrupts apolipoprotein e expression through estrogen-related receptor gamma and dna methlylation in the liver of male rare minnow gobiocypris rarus
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cd04d64e5af14d61843ecfef588218b4
work_keys_str_mv	AT yingyingzhang bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus AT zhuzhu bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus AT qiaoliu bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus AT mengzhang bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus AT huiyang bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus AT wenzhiwei bisphenoladisruptsapolipoproteineexpressionthroughestrogenrelatedreceptorgammaanddnamethlylationintheliverofmalerareminnowgobiocyprisrarus
_version_	1718373056333742080

Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus

Ejemplares similares