Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study

Abstract Complex regional pain syndrome (CRPS) is a common poststroke complication. However, the neural substrates associated with CRPS remain unclear. We investigated the neural correlates associated with poststroke CRPS using voxel-based lesion‒symptom mapping (VLSM) analysis. Among 145 patients w...

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Autores principales:	Jae-Ik Lee, Soon-Woo Kwon, Ahry Lee, Woo-suk Tae, Sung-Bom Pyun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd0642d7c3e74e649c396d42880cef1b
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spelling	oai:doaj.org-article:cd0642d7c3e74e649c396d42880cef1b2021-12-02T17:12:25ZNeuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study10.1038/s41598-021-92564-72045-2322https://doaj.org/article/cd0642d7c3e74e649c396d42880cef1b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92564-7https://doaj.org/toc/2045-2322Abstract Complex regional pain syndrome (CRPS) is a common poststroke complication. However, the neural substrates associated with CRPS remain unclear. We investigated the neural correlates associated with poststroke CRPS using voxel-based lesion‒symptom mapping (VLSM) analysis. Among 145 patients with ischemic stroke, 35 were diagnosed with CRPS and categorized into the poststroke CRPS group, and the remaining 110 into the control group. We compared the clinical characteristics between the groups. VLSM analysis was performed to identify the brain region associated with the development of poststroke CRPS. The clinical findings suggested that the poststroke CRPS group had lower muscle strength; lower scores on Fugl‒Meyer assessment, Manual Function Test, Mini-Mental Status Examination; and higher incidence of absent somatosensory evoked potentials in the median nerve than the control group. The head of the caudate nucleus, putamen, and white matter complexes in the corona radiata were significantly associated with poststroke CRPS development in ischemic stroke patients. These results facilitate an understanding of poststroke CRPS pathophysiology. Monitoring patients with lesions in these structures may aid the prevention and early treatment of poststroke CRPS.Jae-Ik LeeSoon-Woo KwonAhry LeeWoo-suk TaeSung-Bom PyunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae-Ik Lee Soon-Woo Kwon Ahry Lee Woo-suk Tae Sung-Bom Pyun Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
description	Abstract Complex regional pain syndrome (CRPS) is a common poststroke complication. However, the neural substrates associated with CRPS remain unclear. We investigated the neural correlates associated with poststroke CRPS using voxel-based lesion‒symptom mapping (VLSM) analysis. Among 145 patients with ischemic stroke, 35 were diagnosed with CRPS and categorized into the poststroke CRPS group, and the remaining 110 into the control group. We compared the clinical characteristics between the groups. VLSM analysis was performed to identify the brain region associated with the development of poststroke CRPS. The clinical findings suggested that the poststroke CRPS group had lower muscle strength; lower scores on Fugl‒Meyer assessment, Manual Function Test, Mini-Mental Status Examination; and higher incidence of absent somatosensory evoked potentials in the median nerve than the control group. The head of the caudate nucleus, putamen, and white matter complexes in the corona radiata were significantly associated with poststroke CRPS development in ischemic stroke patients. These results facilitate an understanding of poststroke CRPS pathophysiology. Monitoring patients with lesions in these structures may aid the prevention and early treatment of poststroke CRPS.
format	article
author	Jae-Ik Lee Soon-Woo Kwon Ahry Lee Woo-suk Tae Sung-Bom Pyun
author_facet	Jae-Ik Lee Soon-Woo Kwon Ahry Lee Woo-suk Tae Sung-Bom Pyun
author_sort	Jae-Ik Lee
title	Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
title_short	Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
title_full	Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
title_fullStr	Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
title_full_unstemmed	Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
title_sort	neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd0642d7c3e74e649c396d42880cef1b
work_keys_str_mv	AT jaeiklee neuroanatomicalcorrelatesofpoststrokecomplexregionalpainsyndromeavoxelbasedlesionsymptommappingstudy AT soonwookwon neuroanatomicalcorrelatesofpoststrokecomplexregionalpainsyndromeavoxelbasedlesionsymptommappingstudy AT ahrylee neuroanatomicalcorrelatesofpoststrokecomplexregionalpainsyndromeavoxelbasedlesionsymptommappingstudy AT woosuktae neuroanatomicalcorrelatesofpoststrokecomplexregionalpainsyndromeavoxelbasedlesionsymptommappingstudy AT sungbompyun neuroanatomicalcorrelatesofpoststrokecomplexregionalpainsyndromeavoxelbasedlesionsymptommappingstudy
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Neuroanatomical correlates of poststroke complex regional pain syndrome: a voxel-based lesion symptom-mapping study

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