Emerging role of let-7 family in the pathogenesis of hematological malignancies

Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those rela...

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Autores principales:	Fatemeh Yazarlou, Sepideh Kadkhoda, Soudeh Ghafouri-Fard
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer MiRNA Leukemia Let-7 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cd09a7a1404f4975b8f729f42fb5ce39
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spelling	oai:doaj.org-article:cd09a7a1404f4975b8f729f42fb5ce392021-11-14T04:29:55ZEmerging role of let-7 family in the pathogenesis of hematological malignancies0753-332210.1016/j.biopha.2021.112334https://doaj.org/article/cd09a7a1404f4975b8f729f42fb5ce392021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011185https://doaj.org/toc/0753-3322Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those related with MYC. Expression of these miRNAs has been found to be different between distinct hematological malignancies or even between cytogenetically-defined subgroups of a certain malignancy. In the current review, we summarize the data regarding biogenesis, genomic locations, targets and regulatory network of this miRNA family in the context of hematological malignancies.Fatemeh YazarlouSepideh KadkhodaSoudeh Ghafouri-FardElsevierarticleCancerMiRNALeukemiaLet-7Therapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112334- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer MiRNA Leukemia Let-7 Therapeutics. Pharmacology RM1-950
spellingShingle	Cancer MiRNA Leukemia Let-7 Therapeutics. Pharmacology RM1-950 Fatemeh Yazarlou Sepideh Kadkhoda Soudeh Ghafouri-Fard Emerging role of let-7 family in the pathogenesis of hematological malignancies
description	Let-7 includes a family of miRNA which are implicated in the developmental processes as well as carcinogenesis. This miRNA family has been shown to influence pathogenesis of a variety of hematological malignancies through changing expression of a number of oncogenic pathways, particularly those related with MYC. Expression of these miRNAs has been found to be different between distinct hematological malignancies or even between cytogenetically-defined subgroups of a certain malignancy. In the current review, we summarize the data regarding biogenesis, genomic locations, targets and regulatory network of this miRNA family in the context of hematological malignancies.
format	article
author	Fatemeh Yazarlou Sepideh Kadkhoda Soudeh Ghafouri-Fard
author_facet	Fatemeh Yazarlou Sepideh Kadkhoda Soudeh Ghafouri-Fard
author_sort	Fatemeh Yazarlou
title	Emerging role of let-7 family in the pathogenesis of hematological malignancies
title_short	Emerging role of let-7 family in the pathogenesis of hematological malignancies
title_full	Emerging role of let-7 family in the pathogenesis of hematological malignancies
title_fullStr	Emerging role of let-7 family in the pathogenesis of hematological malignancies
title_full_unstemmed	Emerging role of let-7 family in the pathogenesis of hematological malignancies
title_sort	emerging role of let-7 family in the pathogenesis of hematological malignancies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cd09a7a1404f4975b8f729f42fb5ce39
work_keys_str_mv	AT fatemehyazarlou emergingroleoflet7familyinthepathogenesisofhematologicalmalignancies AT sepidehkadkhoda emergingroleoflet7familyinthepathogenesisofhematologicalmalignancies AT soudehghafourifard emergingroleoflet7familyinthepathogenesisofhematologicalmalignancies
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Emerging role of let-7 family in the pathogenesis of hematological malignancies

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