Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.

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Autores principales:	Grigory Ryzhakov, Nathaniel R. West, Fanny Franchini, Simon Clare, Nicholas E. Ilott, Stephen N. Sansom, Samuel J. Bullers, Claire Pearson, Alice Costain, Alun Vaughan-Jackson, Jeremy A. Goettel, Joerg Ermann, Bruce H. Horwitz, Ludovico Buti, Xin Lu, Subhankar Mukhopadhyay, Scott B. Snapper, Fiona Powrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd1515a1c0414a6e99b0e45f27672c4a
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spelling	oai:doaj.org-article:cd1515a1c0414a6e99b0e45f27672c4a2021-12-02T14:38:49ZAlpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis10.1038/s41467-018-06085-52041-1723https://doaj.org/article/cd1515a1c0414a6e99b0e45f27672c4a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06085-5https://doaj.org/toc/2041-1723The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.Grigory RyzhakovNathaniel R. WestFanny FranchiniSimon ClareNicholas E. IlottStephen N. SansomSamuel J. BullersClaire PearsonAlice CostainAlun Vaughan-JacksonJeremy A. GoettelJoerg ErmannBruce H. HorwitzLudovico ButiXin LuSubhankar MukhopadhyayScott B. SnapperFiona PowrieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grigory Ryzhakov Nathaniel R. West Fanny Franchini Simon Clare Nicholas E. Ilott Stephen N. Sansom Samuel J. Bullers Claire Pearson Alice Costain Alun Vaughan-Jackson Jeremy A. Goettel Joerg Ermann Bruce H. Horwitz Ludovico Buti Xin Lu Subhankar Mukhopadhyay Scott B. Snapper Fiona Powrie Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
description	The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.
format	article
author	Grigory Ryzhakov Nathaniel R. West Fanny Franchini Simon Clare Nicholas E. Ilott Stephen N. Sansom Samuel J. Bullers Claire Pearson Alice Costain Alun Vaughan-Jackson Jeremy A. Goettel Joerg Ermann Bruce H. Horwitz Ludovico Buti Xin Lu Subhankar Mukhopadhyay Scott B. Snapper Fiona Powrie
author_facet	Grigory Ryzhakov Nathaniel R. West Fanny Franchini Simon Clare Nicholas E. Ilott Stephen N. Sansom Samuel J. Bullers Claire Pearson Alice Costain Alun Vaughan-Jackson Jeremy A. Goettel Joerg Ermann Bruce H. Horwitz Ludovico Buti Xin Lu Subhankar Mukhopadhyay Scott B. Snapper Fiona Powrie
author_sort	Grigory Ryzhakov
title	Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
title_short	Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
title_full	Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
title_fullStr	Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
title_full_unstemmed	Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
title_sort	alpha kinase 1 controls intestinal inflammation by suppressing the il-12/th1 axis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cd1515a1c0414a6e99b0e45f27672c4a
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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

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