Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

D-cycloserine (DCS) has been used for decades to treat Mycobacterium tuberculosis (Mtb) but resistance is rarely observed in clinical isolates. Here, the authors report ultra-low rate of emergence of resistance mutations as the underlying mechanism of DCS resistance evasion in Mtb.

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Bibliographic Details
Main Authors:	Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/cd1574c81b52465e9b1150a6fda379b5
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spelling	oai:doaj.org-article:cd1574c81b52465e9b1150a6fda379b52021-12-02T16:58:02ZComparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes10.1038/s41467-019-12074-z2041-1723https://doaj.org/article/cd1574c81b52465e9b1150a6fda379b52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12074-zhttps://doaj.org/toc/2041-1723D-cycloserine (DCS) has been used for decades to treat Mycobacterium tuberculosis (Mtb) but resistance is rarely observed in clinical isolates. Here, the authors report ultra-low rate of emergence of resistance mutations as the underlying mechanism of DCS resistance evasion in Mtb.Dimitrios EvangelopoulosGareth A. ProsserAngela RodgersBelinda M. DaggBhagwati KhatriMei Mei HoMaximiliano G. GutierrezTeresa CortesLuiz Pedro S. de CarvalhoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dimitrios Evangelopoulos Gareth A. Prosser Angela Rodgers Belinda M. Dagg Bhagwati Khatri Mei Mei Ho Maximiliano G. Gutierrez Teresa Cortes Luiz Pedro S. de Carvalho Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
description	D-cycloserine (DCS) has been used for decades to treat Mycobacterium tuberculosis (Mtb) but resistance is rarely observed in clinical isolates. Here, the authors report ultra-low rate of emergence of resistance mutations as the underlying mechanism of DCS resistance evasion in Mtb.
format	article
author	Dimitrios Evangelopoulos Gareth A. Prosser Angela Rodgers Belinda M. Dagg Bhagwati Khatri Mei Mei Ho Maximiliano G. Gutierrez Teresa Cortes Luiz Pedro S. de Carvalho
author_facet	Dimitrios Evangelopoulos Gareth A. Prosser Angela Rodgers Belinda M. Dagg Bhagwati Khatri Mei Mei Ho Maximiliano G. Gutierrez Teresa Cortes Luiz Pedro S. de Carvalho
author_sort	Dimitrios Evangelopoulos
title	Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
title_short	Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
title_full	Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
title_fullStr	Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
title_full_unstemmed	Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
title_sort	comparative fitness analysis of d-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cd1574c81b52465e9b1150a6fda379b5
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Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

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