P-glycoprotein and chronic rhinosinusitis

Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable...

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Autores principales:	Marcel M. Miyake, Angela Nocera, Michelle M. Miyake
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/cd178f20e87f485f8b7af4520b10fc8a
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spelling	oai:doaj.org-article:cd178f20e87f485f8b7af4520b10fc8a2021-12-02T11:52:14ZP-glycoprotein and chronic rhinosinusitis2095-881110.1016/j.wjorl.2018.07.002https://doaj.org/article/cd178f20e87f485f8b7af4520b10fc8a2018-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881118300908https://doaj.org/toc/2095-8811Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable side effects. P-glycoprotein (P-gp) is an efflux pump responsible of extruding xenobiotics and cellular metabolites from multiple cell types. It has been widely studied in the cancer field, due to its ability to confer resistance to chemotherapy. It also promotes Type 2 helper T-cell polarizing cytokine secretion in CRS and may represent a potential target to differentiate subtypes of CRS and personalize treatment. This state-of-the-art review explores current knowledge on the participation of P-gp in the pathogenesis of CRS, the P-gp inhibition as a novel targeted therapeutic strategy and the exosomal P-gp test, a non-invasive biomarker that can represent an important advance in the field of rhinology. Keywords: Sinusitis, ATP binding cassette transporter, sub-family B, Verapamil, Exosomes, Nasal polyps, Nasal mucosaMarcel M. MiyakeAngela NoceraMichelle M. MiyakeKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 4, Iss 3, Pp 169-174 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Marcel M. Miyake Angela Nocera Michelle M. Miyake P-glycoprotein and chronic rhinosinusitis
description	Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses. Besides being prevalent, the mechanisms involved in its pathogenesis are not clear and there are few therapeutic options with tolerable side effects. P-glycoprotein (P-gp) is an efflux pump responsible of extruding xenobiotics and cellular metabolites from multiple cell types. It has been widely studied in the cancer field, due to its ability to confer resistance to chemotherapy. It also promotes Type 2 helper T-cell polarizing cytokine secretion in CRS and may represent a potential target to differentiate subtypes of CRS and personalize treatment. This state-of-the-art review explores current knowledge on the participation of P-gp in the pathogenesis of CRS, the P-gp inhibition as a novel targeted therapeutic strategy and the exosomal P-gp test, a non-invasive biomarker that can represent an important advance in the field of rhinology. Keywords: Sinusitis, ATP binding cassette transporter, sub-family B, Verapamil, Exosomes, Nasal polyps, Nasal mucosa
format	article
author	Marcel M. Miyake Angela Nocera Michelle M. Miyake
author_facet	Marcel M. Miyake Angela Nocera Michelle M. Miyake
author_sort	Marcel M. Miyake
title	P-glycoprotein and chronic rhinosinusitis
title_short	P-glycoprotein and chronic rhinosinusitis
title_full	P-glycoprotein and chronic rhinosinusitis
title_fullStr	P-glycoprotein and chronic rhinosinusitis
title_full_unstemmed	P-glycoprotein and chronic rhinosinusitis
title_sort	p-glycoprotein and chronic rhinosinusitis
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/cd178f20e87f485f8b7af4520b10fc8a
work_keys_str_mv	AT marcelmmiyake pglycoproteinandchronicrhinosinusitis AT angelanocera pglycoproteinandchronicrhinosinusitis AT michellemmiyake pglycoproteinandchronicrhinosinusitis
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P-glycoprotein and chronic rhinosinusitis

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