Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics...

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Detalles Bibliográficos
Autores principales: Theresa C. Barrett, Wendy W. K. Mok, Allison M. Murawski, Mark P. Brynildsen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cd187a83369d4ab5ae6d913cf907c073
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Sumario:Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics.