Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics...

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Autores principales:	Theresa C. Barrett, Wendy W. K. Mok, Allison M. Murawski, Mark P. Brynildsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd187a83369d4ab5ae6d913cf907c073
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spelling	oai:doaj.org-article:cd187a83369d4ab5ae6d913cf907c0732021-12-02T17:01:26ZEnhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic10.1038/s41467-019-09058-42041-1723https://doaj.org/article/cd187a83369d4ab5ae6d913cf907c0732019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09058-4https://doaj.org/toc/2041-1723Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics.Theresa C. BarrettWendy W. K. MokAllison M. MurawskiMark P. BrynildsenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Theresa C. Barrett Wendy W. K. Mok Allison M. Murawski Mark P. Brynildsen Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
description	Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics.
format	article
author	Theresa C. Barrett Wendy W. K. Mok Allison M. Murawski Mark P. Brynildsen
author_facet	Theresa C. Barrett Wendy W. K. Mok Allison M. Murawski Mark P. Brynildsen
author_sort	Theresa C. Barrett
title	Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
title_short	Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
title_full	Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
title_fullStr	Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
title_full_unstemmed	Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
title_sort	enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cd187a83369d4ab5ae6d913cf907c073
work_keys_str_mv	AT theresacbarrett enhancedantibioticresistancedevelopmentfromfluoroquinolonepersistersafterasingleexposuretoantibiotic AT wendywkmok enhancedantibioticresistancedevelopmentfromfluoroquinolonepersistersafterasingleexposuretoantibiotic AT allisonmmurawski enhancedantibioticresistancedevelopmentfromfluoroquinolonepersistersafterasingleexposuretoantibiotic AT markpbrynildsen enhancedantibioticresistancedevelopmentfromfluoroquinolonepersistersafterasingleexposuretoantibiotic
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Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

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