Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis

Bin Hu,1 Jinxia Cao,1 Yangyang Hu,2 Zuoan Qin,3 Jun Wang1 1Department of Hematology, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of China; 2Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology...

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Autores principales:	Hu B, Cao J, Hu Y, Qin Z, Wang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	red blood cell distribution width disseminated intravascular coagulation mortality mimic-iii retrospective study Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd1be8b7a16145a28d4238e16e089bfc
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spelling	oai:doaj.org-article:cd1be8b7a16145a28d4238e16e089bfc2021-11-16T18:47:50ZRelationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis1178-7074https://doaj.org/article/cd1be8b7a16145a28d4238e16e089bfc2021-11-01T00:00:00Zhttps://www.dovepress.com/relationship-between-red-blood-cell-distribution-width-and-all-cause-m-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Bin Hu,1 Jinxia Cao,1 Yangyang Hu,2 Zuoan Qin,3 Jun Wang1 1Department of Hematology, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of China; 2Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Cardiovascular Medicine, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of ChinaCorrespondence: Jun WangDepartment of Hematology, First People’s Hospital of Changde City, 818 Renmin Road, Wuling District, Changde, 415000, Hunan, People’s Republic of ChinaTel +86-736-7788720Email xueyeke2020@sina.comPurpose: Studies regarding death risk factors of disseminated intravascular coagulation (DIC) patients were limited. We conducted this study to investigate whether red blood cell distribution width (RDW) was independently related to all-cause mortality of DIC patients.Methods: We used data from the Medical Information Mart for Intensive Care III version 1.4 (MIMIC-III v1.4). A total of 2098 patients with DIC were included. The main outcome was in-hospital all-cause mortality.Results: After adjusting for potential covariates, the in-hospital all-cause mortality was positively correlated with RDW. The hazard ratio (HR), 95% confidence intervals (CI), and P-value were 1.08, (1.05, 1.12), and P< 0.0001, respectively. The Kaplan–Meier curve found DIC patients with elevated RDW had a lower survival rate than patients with normal RDW (P< 0.0001). A nonlinear relationship between RDW and mortality was found with the inflection point 19.2%. When RDW < 19.2%, RDW was positively correlated with in-hospital all-cause mortality of DIC patients (HR (95% CI): 1.17 (1.11, 1.24), P< 0.0001). An elevation in RDW greater than 19.2% did not result in an additional increased risk of mortality (HR=0.97, 95% CI: 0.91– 1.04, P=0.4617).Conclusion: RDW is an independent predictor of all-cause mortality in DIC patients. Furthermore, there is a nonlinear association between RDW and all-cause mortality of DIC patients.Keywords: red blood cell distribution width, disseminated intravascular coagulation, mortality, MIMIC-III, retrospective studyHu BCao JHu YQin ZWang JDove Medical Pressarticlered blood cell distribution widthdisseminated intravascular coagulationmortalitymimic-iiiretrospective studyMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8301-8309 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	red blood cell distribution width disseminated intravascular coagulation mortality mimic-iii retrospective study Medicine (General) R5-920
spellingShingle	red blood cell distribution width disseminated intravascular coagulation mortality mimic-iii retrospective study Medicine (General) R5-920 Hu B Cao J Hu Y Qin Z Wang J Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
description	Bin Hu,1 Jinxia Cao,1 Yangyang Hu,2 Zuoan Qin,3 Jun Wang1 1Department of Hematology, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of China; 2Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Cardiovascular Medicine, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of ChinaCorrespondence: Jun WangDepartment of Hematology, First People’s Hospital of Changde City, 818 Renmin Road, Wuling District, Changde, 415000, Hunan, People’s Republic of ChinaTel +86-736-7788720Email xueyeke2020@sina.comPurpose: Studies regarding death risk factors of disseminated intravascular coagulation (DIC) patients were limited. We conducted this study to investigate whether red blood cell distribution width (RDW) was independently related to all-cause mortality of DIC patients.Methods: We used data from the Medical Information Mart for Intensive Care III version 1.4 (MIMIC-III v1.4). A total of 2098 patients with DIC were included. The main outcome was in-hospital all-cause mortality.Results: After adjusting for potential covariates, the in-hospital all-cause mortality was positively correlated with RDW. The hazard ratio (HR), 95% confidence intervals (CI), and P-value were 1.08, (1.05, 1.12), and P< 0.0001, respectively. The Kaplan–Meier curve found DIC patients with elevated RDW had a lower survival rate than patients with normal RDW (P< 0.0001). A nonlinear relationship between RDW and mortality was found with the inflection point 19.2%. When RDW < 19.2%, RDW was positively correlated with in-hospital all-cause mortality of DIC patients (HR (95% CI): 1.17 (1.11, 1.24), P< 0.0001). An elevation in RDW greater than 19.2% did not result in an additional increased risk of mortality (HR=0.97, 95% CI: 0.91– 1.04, P=0.4617).Conclusion: RDW is an independent predictor of all-cause mortality in DIC patients. Furthermore, there is a nonlinear association between RDW and all-cause mortality of DIC patients.Keywords: red blood cell distribution width, disseminated intravascular coagulation, mortality, MIMIC-III, retrospective study
format	article
author	Hu B Cao J Hu Y Qin Z Wang J
author_facet	Hu B Cao J Hu Y Qin Z Wang J
author_sort	Hu B
title	Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
title_short	Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
title_full	Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
title_fullStr	Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
title_full_unstemmed	Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis
title_sort	relationship between red blood cell distribution width and all-cause mortality in disseminated intravascular coagulation patients: a retrospective analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/cd1be8b7a16145a28d4238e16e089bfc
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Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis

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