Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study
Abstract Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a...
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2021
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oai:doaj.org-article:cd1dcfad42b342a8af535c89f3c3dd992021-12-02T10:44:15ZDevelopment of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study10.1038/s41598-021-82712-42045-2322https://doaj.org/article/cd1dcfad42b342a8af535c89f3c3dd992021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82712-4https://doaj.org/toc/2045-2322Abstract Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents.Miguel Seral-CortesSergio Sabroso-LasaPilar De Miguel-EtayoMarcela Gonzalez-GrossEva GesteiroCristina Molina-HidalgoStefaan De HenauwFrederic GottrandChristina MavrogianniYannis ManiosMaria PladaKurt WidhalmAnthony KafatosÉva ErhardtAline MeirhaegheDiego Salazar-TortosaJonatan RuizLuis A. MorenoLuis Mariano EstebanIdoia LabayenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Miguel Seral-Cortes Sergio Sabroso-Lasa Pilar De Miguel-Etayo Marcela Gonzalez-Gross Eva Gesteiro Cristina Molina-Hidalgo Stefaan De Henauw Frederic Gottrand Christina Mavrogianni Yannis Manios Maria Plada Kurt Widhalm Anthony Kafatos Éva Erhardt Aline Meirhaeghe Diego Salazar-Tortosa Jonatan Ruiz Luis A. Moreno Luis Mariano Esteban Idoia Labayen Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| description |
Abstract Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents. |
| format |
article |
| author |
Miguel Seral-Cortes Sergio Sabroso-Lasa Pilar De Miguel-Etayo Marcela Gonzalez-Gross Eva Gesteiro Cristina Molina-Hidalgo Stefaan De Henauw Frederic Gottrand Christina Mavrogianni Yannis Manios Maria Plada Kurt Widhalm Anthony Kafatos Éva Erhardt Aline Meirhaeghe Diego Salazar-Tortosa Jonatan Ruiz Luis A. Moreno Luis Mariano Esteban Idoia Labayen |
| author_facet |
Miguel Seral-Cortes Sergio Sabroso-Lasa Pilar De Miguel-Etayo Marcela Gonzalez-Gross Eva Gesteiro Cristina Molina-Hidalgo Stefaan De Henauw Frederic Gottrand Christina Mavrogianni Yannis Manios Maria Plada Kurt Widhalm Anthony Kafatos Éva Erhardt Aline Meirhaeghe Diego Salazar-Tortosa Jonatan Ruiz Luis A. Moreno Luis Mariano Esteban Idoia Labayen |
| author_sort |
Miguel Seral-Cortes |
| title |
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| title_short |
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| title_full |
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| title_fullStr |
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| title_full_unstemmed |
Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
| title_sort |
development of a genetic risk score to predict the risk of overweight and obesity in european adolescents from the helena study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/cd1dcfad42b342a8af535c89f3c3dd99 |
| work_keys_str_mv |
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