Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels

Abstract In recent years, PCR-based methods as a rapid and high accurate technique in the industry and medical fields have been expanded rapidly. Where we are faced with the COVID-19 pandemic, the necessity of a rapid diagnosis has felt more than ever. In the current interdisciplinary study, we have...

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Autores principales:	Yousef Alihosseini, Mohammad Reza Azaddel, Sahel Moslemi, Mehdi Mohammadi, Ali Pormohammad, Mohammad Zabetian Targhi, Mohammad Mahdi Heyhat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd1e61ad32a546e0b02820931aa7fa6e
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spelling	oai:doaj.org-article:cd1e61ad32a546e0b02820931aa7fa6e2021-12-02T15:07:55ZEffect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels10.1038/s41598-021-95446-02045-2322https://doaj.org/article/cd1e61ad32a546e0b02820931aa7fa6e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95446-0https://doaj.org/toc/2045-2322Abstract In recent years, PCR-based methods as a rapid and high accurate technique in the industry and medical fields have been expanded rapidly. Where we are faced with the COVID-19 pandemic, the necessity of a rapid diagnosis has felt more than ever. In the current interdisciplinary study, we have proposed, developed, and characterized a state-of-the-art liquid cooling design to accelerate the PCR procedure. A numerical simulation approach is utilized to evaluate 15 different cross-sections of the microchannel heat sink and select the best shape to achieve this goal. Also, crucial heat sink parameters are characterized, e.g., heat transfer coefficient, pressure drop, performance evaluation criteria, and fluid flow. The achieved result showed that the circular cross-section is the most efficient shape for the microchannel heat sink, which has a maximum heat transfer enhancement of 25% compared to the square shape at the Reynolds number of 1150. In the next phase of the study, the circular cross-section microchannel is located below the PCR device to evaluate the cooling rate of the PCR. Also, the results demonstrate that it takes 16.5 s to cool saliva samples in the PCR well, which saves up to 157.5 s for the whole amplification procedure compared to the conventional air fans. Another advantage of using the microchannel heat sink is that it takes up a little space compared to other common cooling methods.Yousef AlihosseiniMohammad Reza AzaddelSahel MoslemiMehdi MohammadiAli PormohammadMohammad Zabetian TarghiMohammad Mahdi HeyhatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yousef Alihosseini Mohammad Reza Azaddel Sahel Moslemi Mehdi Mohammadi Ali Pormohammad Mohammad Zabetian Targhi Mohammad Mahdi Heyhat Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
description	Abstract In recent years, PCR-based methods as a rapid and high accurate technique in the industry and medical fields have been expanded rapidly. Where we are faced with the COVID-19 pandemic, the necessity of a rapid diagnosis has felt more than ever. In the current interdisciplinary study, we have proposed, developed, and characterized a state-of-the-art liquid cooling design to accelerate the PCR procedure. A numerical simulation approach is utilized to evaluate 15 different cross-sections of the microchannel heat sink and select the best shape to achieve this goal. Also, crucial heat sink parameters are characterized, e.g., heat transfer coefficient, pressure drop, performance evaluation criteria, and fluid flow. The achieved result showed that the circular cross-section is the most efficient shape for the microchannel heat sink, which has a maximum heat transfer enhancement of 25% compared to the square shape at the Reynolds number of 1150. In the next phase of the study, the circular cross-section microchannel is located below the PCR device to evaluate the cooling rate of the PCR. Also, the results demonstrate that it takes 16.5 s to cool saliva samples in the PCR well, which saves up to 157.5 s for the whole amplification procedure compared to the conventional air fans. Another advantage of using the microchannel heat sink is that it takes up a little space compared to other common cooling methods.
format	article
author	Yousef Alihosseini Mohammad Reza Azaddel Sahel Moslemi Mehdi Mohammadi Ali Pormohammad Mohammad Zabetian Targhi Mohammad Mahdi Heyhat
author_facet	Yousef Alihosseini Mohammad Reza Azaddel Sahel Moslemi Mehdi Mohammadi Ali Pormohammad Mohammad Zabetian Targhi Mohammad Mahdi Heyhat
author_sort	Yousef Alihosseini
title	Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
title_short	Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
title_full	Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
title_fullStr	Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
title_full_unstemmed	Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels
title_sort	effect of liquid cooling on pcr performance with the parametric study of cross-section shapes of microchannels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd1e61ad32a546e0b02820931aa7fa6e
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Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels

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