A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis
In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE®) was evaluated. At the end of the trial (133 days), in order t...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cd1fddc44f244b328a89ca2e4b956700 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cd1fddc44f244b328a89ca2e4b956700 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cd1fddc44f244b328a89ca2e4b9567002021-11-12T06:56:29ZA Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis1664-322410.3389/fimmu.2021.737601https://doaj.org/article/cd1fddc44f244b328a89ca2e4b9567002021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.737601/fullhttps://doaj.org/toc/1664-3224In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE®) was evaluated. At the end of the trial (133 days), in order to investigate the immunomodulatory properties of the phytogenic tested against a bacterial infection, an in vivo challenge with Aeromonas salmonicida was performed. A total number of 1,027 differentially expressed genes (DEGs) (805 up- and 222 downregulated) were found when comparing the transcriptomic profiling of the HK from fish fed the control and AQUOLIVE® diets. The HK transcripteractome revealed an expression profile that mainly favored biological processes related to immunity. Particularly, the signaling of i-kappa B kinase/NF-kappa and the activation of leukocytes, such as granulocytes and neutrophils degranulation, were suggested to be the primary actors of the innate immune response promoted by the tested functional feed additive in the HK. Moreover, the bacterial challenge with A. salmonicida that lasted 12 days showed that the cumulative survival was higher in fish fed the AQUOLIVE® diet (96.9 ± 6.4%) than the control group (60.7 ± 13.5%). These results indicate that the dietary supplementation of AQUOLIVE® at the level of 0.15% enhanced the systemic immune response and reduced the A. salmonicida cumulative mortality in Atlantic salmon smolts.Ricardo SalomónRicardo SalomónM. Dolors FuronesFelipe E. Reyes-LópezFelipe E. Reyes-LópezFelipe E. Reyes-LópezLluis TortJoana P. FirminoM. Angeles EstebanCristóbal Espinosa RuízJosé C. QuintelaJosé M. Pinilla-RosasEva Vallejos-VidalEnric GisbertFrontiers Media S.A.articlefeed additiveOlea europaeaaquacultureAeromonas salmonicidachallengesystemic immunityImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
feed additive Olea europaea aquaculture Aeromonas salmonicida challenge systemic immunity Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
feed additive Olea europaea aquaculture Aeromonas salmonicida challenge systemic immunity Immunologic diseases. Allergy RC581-607 Ricardo Salomón Ricardo Salomón M. Dolors Furones Felipe E. Reyes-López Felipe E. Reyes-López Felipe E. Reyes-López Lluis Tort Joana P. Firmino M. Angeles Esteban Cristóbal Espinosa Ruíz José C. Quintela José M. Pinilla-Rosas Eva Vallejos-Vidal Enric Gisbert A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| description |
In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE®) was evaluated. At the end of the trial (133 days), in order to investigate the immunomodulatory properties of the phytogenic tested against a bacterial infection, an in vivo challenge with Aeromonas salmonicida was performed. A total number of 1,027 differentially expressed genes (DEGs) (805 up- and 222 downregulated) were found when comparing the transcriptomic profiling of the HK from fish fed the control and AQUOLIVE® diets. The HK transcripteractome revealed an expression profile that mainly favored biological processes related to immunity. Particularly, the signaling of i-kappa B kinase/NF-kappa and the activation of leukocytes, such as granulocytes and neutrophils degranulation, were suggested to be the primary actors of the innate immune response promoted by the tested functional feed additive in the HK. Moreover, the bacterial challenge with A. salmonicida that lasted 12 days showed that the cumulative survival was higher in fish fed the AQUOLIVE® diet (96.9 ± 6.4%) than the control group (60.7 ± 13.5%). These results indicate that the dietary supplementation of AQUOLIVE® at the level of 0.15% enhanced the systemic immune response and reduced the A. salmonicida cumulative mortality in Atlantic salmon smolts. |
| format |
article |
| author |
Ricardo Salomón Ricardo Salomón M. Dolors Furones Felipe E. Reyes-López Felipe E. Reyes-López Felipe E. Reyes-López Lluis Tort Joana P. Firmino M. Angeles Esteban Cristóbal Espinosa Ruíz José C. Quintela José M. Pinilla-Rosas Eva Vallejos-Vidal Enric Gisbert |
| author_facet |
Ricardo Salomón Ricardo Salomón M. Dolors Furones Felipe E. Reyes-López Felipe E. Reyes-López Felipe E. Reyes-López Lluis Tort Joana P. Firmino M. Angeles Esteban Cristóbal Espinosa Ruíz José C. Quintela José M. Pinilla-Rosas Eva Vallejos-Vidal Enric Gisbert |
| author_sort |
Ricardo Salomón |
| title |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| title_short |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| title_full |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| title_fullStr |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| title_full_unstemmed |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
| title_sort |
bioactive extract rich in triterpenic acid and polyphenols from olea europaea promotes systemic immunity and protects atlantic salmon smolts against furunculosis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/cd1fddc44f244b328a89ca2e4b956700 |
| work_keys_str_mv |
AT ricardosalomon abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT ricardosalomon abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT mdolorsfurones abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT lluistort abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT joanapfirmino abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT mangelesesteban abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT cristobalespinosaruiz abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT josecquintela abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT josempinillarosas abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT evavallejosvidal abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT enricgisbert abioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT ricardosalomon bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT ricardosalomon bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT mdolorsfurones bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT felipeereyeslopez bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT lluistort bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT joanapfirmino bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT mangelesesteban bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT cristobalespinosaruiz bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT josecquintela bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT josempinillarosas bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT evavallejosvidal bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis AT enricgisbert bioactiveextractrichintriterpenicacidandpolyphenolsfromoleaeuropaeapromotessystemicimmunityandprotectsatlanticsalmonsmoltsagainstfurunculosis |
| _version_ |
1718431137067433984 |