A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.
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Nature Portfolio
2021
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oai:doaj.org-article:cd230e45dae0415ca0fb2fb0eaf34de22021-12-02T13:34:55ZA critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy10.1038/s41467-021-21649-82041-1723https://doaj.org/article/cd230e45dae0415ca0fb2fb0eaf34de22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21649-8https://doaj.org/toc/2041-1723Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.Zane R. LybrandSonal GoswamiJingfei ZhuVeronica JarzabekNikolas MerlockMahafuza AktarCourtney SmithLing ZhangParul VarmaKyung-Ok ChoShaoyu GeJenny HsiehNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
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Science Q Zane R. Lybrand Sonal Goswami Jingfei Zhu Veronica Jarzabek Nikolas Merlock Mahafuza Aktar Courtney Smith Ling Zhang Parul Varma Kyung-Ok Cho Shaoyu Ge Jenny Hsieh A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| description |
Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy. |
| format |
article |
| author |
Zane R. Lybrand Sonal Goswami Jingfei Zhu Veronica Jarzabek Nikolas Merlock Mahafuza Aktar Courtney Smith Ling Zhang Parul Varma Kyung-Ok Cho Shaoyu Ge Jenny Hsieh |
| author_facet |
Zane R. Lybrand Sonal Goswami Jingfei Zhu Veronica Jarzabek Nikolas Merlock Mahafuza Aktar Courtney Smith Ling Zhang Parul Varma Kyung-Ok Cho Shaoyu Ge Jenny Hsieh |
| author_sort |
Zane R. Lybrand |
| title |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| title_short |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| title_full |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| title_fullStr |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| title_full_unstemmed |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| title_sort |
critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/cd230e45dae0415ca0fb2fb0eaf34de2 |
| work_keys_str_mv |
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