A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.

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Bibliographic Details
Main Authors: Zane R. Lybrand, Sonal Goswami, Jingfei Zhu, Veronica Jarzabek, Nikolas Merlock, Mahafuza Aktar, Courtney Smith, Ling Zhang, Parul Varma, Kyung-Ok Cho, Shaoyu Ge, Jenny Hsieh
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/cd230e45dae0415ca0fb2fb0eaf34de2
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https://doaj.org/article/cd230e45dae0415ca0fb2fb0eaf34de2

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