Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats

Kompleksna klinička slika neuropatije nakon povrede perifernog nerva često je praćena i promenama afektivnog stanja pacijenata. U animalnim modelima bola pokazano je da pozitivni alosterni modulatori GABAA receptora mogu da smanje nociceptivnu transmisiju. Međutim, skorašnji nalazi ukazuju i na mogu...

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Autores principales:	Obradović Lj. Aleksandar, Joksimović Srđan, M. Poe Michael, Timić Tamara, M.Cook James, M. Savić Miroslav
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	benzodiazepines elevated plus maze nerve crush injury spontaneous locomotor activity wistar rats Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/cd2610633a3d4bbf8aa9dab522099c72
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spelling	oai:doaj.org-article:cd2610633a3d4bbf8aa9dab522099c722021-11-17T21:27:52ZDelayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats1820-744810.2478/acve-2014-0018https://doaj.org/article/cd2610633a3d4bbf8aa9dab522099c722014-06-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0018https://doaj.org/toc/1820-7448Kompleksna klinička slika neuropatije nakon povrede perifernog nerva često je praćena i promenama afektivnog stanja pacijenata. U animalnim modelima bola pokazano je da pozitivni alosterni modulatori GABAA receptora mogu da smanje nociceptivnu transmisiju. Međutim, skorašnji nalazi ukazuju i na mogućnost da je prividni antinociceptivni efekat benzodiazepina nakon delovanja akutnog bolnog stimulusa u značajnoj meri posledica anksiolitičnog efekta.Obradović Lj. AleksandarJoksimović SrđanM. Poe MichaelTimić TamaraM.Cook JamesM. Savić MiroslavSciendoarticlebenzodiazepines elevated plus mazenerve crush injuryspontaneous locomotor activitywistar ratsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 2, Pp 189-199 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzodiazepines elevated plus maze nerve crush injury spontaneous locomotor activity wistar rats Veterinary medicine SF600-1100
spellingShingle	benzodiazepines elevated plus maze nerve crush injury spontaneous locomotor activity wistar rats Veterinary medicine SF600-1100 Obradović Lj. Aleksandar Joksimović Srđan M. Poe Michael Timić Tamara M.Cook James M. Savić Miroslav Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
description	Kompleksna klinička slika neuropatije nakon povrede perifernog nerva često je praćena i promenama afektivnog stanja pacijenata. U animalnim modelima bola pokazano je da pozitivni alosterni modulatori GABAA receptora mogu da smanje nociceptivnu transmisiju. Međutim, skorašnji nalazi ukazuju i na mogućnost da je prividni antinociceptivni efekat benzodiazepina nakon delovanja akutnog bolnog stimulusa u značajnoj meri posledica anksiolitičnog efekta.
format	article
author	Obradović Lj. Aleksandar Joksimović Srđan M. Poe Michael Timić Tamara M.Cook James M. Savić Miroslav
author_facet	Obradović Lj. Aleksandar Joksimović Srđan M. Poe Michael Timić Tamara M.Cook James M. Savić Miroslav
author_sort	Obradović Lj. Aleksandar
title	Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
title_short	Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
title_full	Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
title_fullStr	Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
title_full_unstemmed	Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats
title_sort	delayed behavioral effects of sh–i–048a, a novel nonselective positive modulator of gabaa receptors, after peripheral nerve injury in rats
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/cd2610633a3d4bbf8aa9dab522099c72
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Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats

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