Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome

Dermatomyositis (DM) is a rheumatological disorder characterized by proximal myositis and distinctive dermatological manifestations. It can be an isolated clinical syndrome or, in rarer cases, can be the initial presentation for an underlying malignancy as a part of a paraneoplastic syndrome. In thi...

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Autores principales:	Reham Almasoud, Rasha Alloush, Labib Al-Ozaibi
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	colon adenocarcinoma dermatomyositis microangiopathic hemolytic anemia paraneoplastic syndrome surgery Medicine R
Acceso en línea:	https://doaj.org/article/cd2a577ba4a647f0a32bfe9bbac0eb3e
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spelling	oai:doaj.org-article:cd2a577ba4a647f0a32bfe9bbac0eb3e2021-11-04T14:40:32ZColon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome2571-726X10.1159/000518882https://doaj.org/article/cd2a577ba4a647f0a32bfe9bbac0eb3e2021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/518882https://doaj.org/toc/2571-726XDermatomyositis (DM) is a rheumatological disorder characterized by proximal myositis and distinctive dermatological manifestations. It can be an isolated clinical syndrome or, in rarer cases, can be the initial presentation for an underlying malignancy as a part of a paraneoplastic syndrome. In this case report, we describe a case of a 51-year-old lady who presented with proximal myopathy, typical DM skin rash, dysphagia, and markedly elevated creatine kinase. She was diagnosed with a seronegative DM and her malignancy screening revealed a mass in the ascending colon. During her hospital course, she also developed microangiopathic hemolytic anemia, another paraneoplastic disorder typically associated with late stages of malignancy, manifested as hemolytic anemia, thrombocytopenia, and low fibrinogen. The patient received intravenous corticosteroids and underwent tumor resection with following resolution of her both rheumatological and hematological manifestation. Unfortunately, due to her general poor health, she developed sepsis and died in the hospital.Reham AlmasoudRasha AlloushLabib Al-OzaibiKarger Publishersarticlecolon adenocarcinomadermatomyositismicroangiopathic hemolytic anemiaparaneoplastic syndromesurgeryMedicineRENDubai Medical Journal, Pp 1-3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon adenocarcinoma dermatomyositis microangiopathic hemolytic anemia paraneoplastic syndrome surgery Medicine R
spellingShingle	colon adenocarcinoma dermatomyositis microangiopathic hemolytic anemia paraneoplastic syndrome surgery Medicine R Reham Almasoud Rasha Alloush Labib Al-Ozaibi Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
description	Dermatomyositis (DM) is a rheumatological disorder characterized by proximal myositis and distinctive dermatological manifestations. It can be an isolated clinical syndrome or, in rarer cases, can be the initial presentation for an underlying malignancy as a part of a paraneoplastic syndrome. In this case report, we describe a case of a 51-year-old lady who presented with proximal myopathy, typical DM skin rash, dysphagia, and markedly elevated creatine kinase. She was diagnosed with a seronegative DM and her malignancy screening revealed a mass in the ascending colon. During her hospital course, she also developed microangiopathic hemolytic anemia, another paraneoplastic disorder typically associated with late stages of malignancy, manifested as hemolytic anemia, thrombocytopenia, and low fibrinogen. The patient received intravenous corticosteroids and underwent tumor resection with following resolution of her both rheumatological and hematological manifestation. Unfortunately, due to her general poor health, she developed sepsis and died in the hospital.
format	article
author	Reham Almasoud Rasha Alloush Labib Al-Ozaibi
author_facet	Reham Almasoud Rasha Alloush Labib Al-Ozaibi
author_sort	Reham Almasoud
title	Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
title_short	Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
title_full	Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
title_fullStr	Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
title_full_unstemmed	Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome
title_sort	colon cancer: an unusual presentation with a paraneoplastic syndrome
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/cd2a577ba4a647f0a32bfe9bbac0eb3e
work_keys_str_mv	AT rehamalmasoud coloncanceranunusualpresentationwithaparaneoplasticsyndrome AT rashaalloush coloncanceranunusualpresentationwithaparaneoplasticsyndrome AT labibalozaibi coloncanceranunusualpresentationwithaparaneoplasticsyndrome
_version_	1718444868840194048

Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome

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