Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy

Biodegradable membranes are used in regenerative dentistry for guided tissue regeneration (GTR) and guided bone regeneration (GBR). In this study, patterned poly(lactic-<i>co</i>-glycolic acid) (PLGA) membranes with groove, pillar, and hole structures were successfully fabricated by ther...

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Autores principales:	Naoyuki Kaga, Hiroki Fujimoto, Sho Morita, Yuichiro Yamaguchi, Takashi Matsuura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	micro/nano pattern poly(lactic-<i>co</i>-glycolic acid) contact angle cell adhesion nanoimprint guided tissue regeneration Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/cd2ae533e48d48e68528e9eb29116d13
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spelling	oai:doaj.org-article:cd2ae533e48d48e68528e9eb29116d132021-11-25T17:19:55ZContact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy10.3390/dj91101242304-6767https://doaj.org/article/cd2ae533e48d48e68528e9eb29116d132021-10-01T00:00:00Zhttps://www.mdpi.com/2304-6767/9/11/124https://doaj.org/toc/2304-6767Biodegradable membranes are used in regenerative dentistry for guided tissue regeneration (GTR) and guided bone regeneration (GBR). In this study, patterned poly(lactic-<i>co</i>-glycolic acid) (PLGA) membranes with groove, pillar, and hole structures were successfully fabricated by thermal nanoimprinting. Their surfaces were evaluated for topography by scanning electron microscopy and laser microscopy, for hydrophobicity/hydrophilicity by contact angle analysis, and for MC3T3-E1 cell adhesion. The sizes of the patterns on the surfaces of the membranes were 0.5, 1.0, and 2.0 μm, respectively, with the height/depth being 1.0 μm. The pillared and holed PLGA membranes were significantly more hydrophobic than the non-patterned PLGA membranes (<i>p</i> < 0.05). However, the 0.5 μm- and 1.0 μm-grooved PLGA membranes were significantly more hydrophilic than the non-patterned PLGA membranes (<i>p</i> < 0.05). The 0.5 μm-grooved, pillared, and holed membranes exhibited significantly superior adhesion to the MC3T3-E1 cells than the non-patterned PLGA (<i>p</i> < 0.05). These results suggest that patterned PLGA membranes can be clinically used for GTR and GBR in the dental regeneration field.Naoyuki KagaHiroki FujimotoSho MoritaYuichiro YamaguchiTakashi MatsuuraMDPI AGarticlemicro/nano patternpoly(lactic-<i>co</i>-glycolic acid)contact anglecell adhesionnanoimprintguided tissue regenerationDentistryRK1-715ENDentistry Journal, Vol 9, Iss 124, p 124 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	micro/nano pattern poly(lactic-<i>co</i>-glycolic acid) contact angle cell adhesion nanoimprint guided tissue regeneration Dentistry RK1-715
spellingShingle	micro/nano pattern poly(lactic-<i>co</i>-glycolic acid) contact angle cell adhesion nanoimprint guided tissue regeneration Dentistry RK1-715 Naoyuki Kaga Hiroki Fujimoto Sho Morita Yuichiro Yamaguchi Takashi Matsuura Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
description	Biodegradable membranes are used in regenerative dentistry for guided tissue regeneration (GTR) and guided bone regeneration (GBR). In this study, patterned poly(lactic-<i>co</i>-glycolic acid) (PLGA) membranes with groove, pillar, and hole structures were successfully fabricated by thermal nanoimprinting. Their surfaces were evaluated for topography by scanning electron microscopy and laser microscopy, for hydrophobicity/hydrophilicity by contact angle analysis, and for MC3T3-E1 cell adhesion. The sizes of the patterns on the surfaces of the membranes were 0.5, 1.0, and 2.0 μm, respectively, with the height/depth being 1.0 μm. The pillared and holed PLGA membranes were significantly more hydrophobic than the non-patterned PLGA membranes (<i>p</i> < 0.05). However, the 0.5 μm- and 1.0 μm-grooved PLGA membranes were significantly more hydrophilic than the non-patterned PLGA membranes (<i>p</i> < 0.05). The 0.5 μm-grooved, pillared, and holed membranes exhibited significantly superior adhesion to the MC3T3-E1 cells than the non-patterned PLGA (<i>p</i> < 0.05). These results suggest that patterned PLGA membranes can be clinically used for GTR and GBR in the dental regeneration field.
format	article
author	Naoyuki Kaga Hiroki Fujimoto Sho Morita Yuichiro Yamaguchi Takashi Matsuura
author_facet	Naoyuki Kaga Hiroki Fujimoto Sho Morita Yuichiro Yamaguchi Takashi Matsuura
author_sort	Naoyuki Kaga
title	Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
title_short	Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
title_full	Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
title_fullStr	Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
title_full_unstemmed	Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy
title_sort	contact angle and cell adhesion of micro/nano-structured poly(lactic-<i>co</i>-glycolic acid) membranes for dental regenerative therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cd2ae533e48d48e68528e9eb29116d13
work_keys_str_mv	AT naoyukikaga contactangleandcelladhesionofmicronanostructuredpolylacticicoiglycolicacidmembranesfordentalregenerativetherapy AT hirokifujimoto contactangleandcelladhesionofmicronanostructuredpolylacticicoiglycolicacidmembranesfordentalregenerativetherapy AT shomorita contactangleandcelladhesionofmicronanostructuredpolylacticicoiglycolicacidmembranesfordentalregenerativetherapy AT yuichiroyamaguchi contactangleandcelladhesionofmicronanostructuredpolylacticicoiglycolicacidmembranesfordentalregenerativetherapy AT takashimatsuura contactangleandcelladhesionofmicronanostructuredpolylacticicoiglycolicacidmembranesfordentalregenerativetherapy
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Contact Angle and Cell Adhesion of Micro/Nano-Structured Poly(lactic-<i>co</i>-glycolic acid) Membranes for Dental Regenerative Therapy

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