Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves

Abstract The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesian bulls. Holstein-Friesian bull calves with a mean (±S.D.) age and bodyweight of 19 (±8...

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Autores principales:	A. M. English, C. J. Byrne, P Cormican, S. M. Waters, S. Fair, D. A. Kenny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Holstein-Friesian Bulls Early Calf-hood Lower Plane Higher Plane Anterior Pituitary Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd2b45de272242b3a9120e2137bc196f
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spelling	oai:doaj.org-article:cd2b45de272242b3a9120e2137bc196f2021-12-02T15:08:35ZEffect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves10.1038/s41598-018-34611-42045-2322https://doaj.org/article/cd2b45de272242b3a9120e2137bc196f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34611-4https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesian bulls. Holstein-Friesian bull calves with a mean (±S.D.) age and bodyweight of 19 (±8.2) days and 47.5 (±5.3) kg, respectively, were offered a high (n = 10) or low (n = 10) plane of nutrition in order to achieve an overall growth rate of 1.2 and 0.5 kg/day. At 126 (±3) days of age, calves were euthanized, hypothalamus (arcuate region), anterior pituitary and testicular parenchyma samples were harvested and RNAseq analysis was performed. There were 0, 49 and 1,346 genes differentially expressed in the arcuate nucleus, anterior pituitary and testicular tissue of bull calves on the low relative to the high plane of nutrition, respectively (P < 0.05; False Discovery Rate <0.05). Cell cycle processes in the anterior pituitary were down regulated in the low relative to the high plane of nutrition; there was no differential expression of genes related to reproductive processes. Gene expression involved in cholesterol and androgen biosynthesis in the testes were down regulated in animals on the low plane of nutrition. This study provides insight into the effect of early life plane of nutrition on the regulation of the HPT axis.A. M. EnglishC. J. ByrneP CormicanS. M. WatersS. FairD. A. KennyNature PortfolioarticleHolstein-Friesian BullsEarly Calf-hoodLower PlaneHigher PlaneAnterior PituitaryMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Holstein-Friesian Bulls Early Calf-hood Lower Plane Higher Plane Anterior Pituitary Medicine R Science Q
spellingShingle	Holstein-Friesian Bulls Early Calf-hood Lower Plane Higher Plane Anterior Pituitary Medicine R Science Q A. M. English C. J. Byrne P Cormican S. M. Waters S. Fair D. A. Kenny Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
description	Abstract The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of the arcuate nucleus of the hypothalamus, anterior pituitary and testes in Holstein-Friesian bulls. Holstein-Friesian bull calves with a mean (±S.D.) age and bodyweight of 19 (±8.2) days and 47.5 (±5.3) kg, respectively, were offered a high (n = 10) or low (n = 10) plane of nutrition in order to achieve an overall growth rate of 1.2 and 0.5 kg/day. At 126 (±3) days of age, calves were euthanized, hypothalamus (arcuate region), anterior pituitary and testicular parenchyma samples were harvested and RNAseq analysis was performed. There were 0, 49 and 1,346 genes differentially expressed in the arcuate nucleus, anterior pituitary and testicular tissue of bull calves on the low relative to the high plane of nutrition, respectively (P < 0.05; False Discovery Rate <0.05). Cell cycle processes in the anterior pituitary were down regulated in the low relative to the high plane of nutrition; there was no differential expression of genes related to reproductive processes. Gene expression involved in cholesterol and androgen biosynthesis in the testes were down regulated in animals on the low plane of nutrition. This study provides insight into the effect of early life plane of nutrition on the regulation of the HPT axis.
format	article
author	A. M. English C. J. Byrne P Cormican S. M. Waters S. Fair D. A. Kenny
author_facet	A. M. English C. J. Byrne P Cormican S. M. Waters S. Fair D. A. Kenny
author_sort	A. M. English
title	Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
title_short	Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
title_full	Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
title_fullStr	Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
title_full_unstemmed	Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves
title_sort	effect of early calf-hood nutrition on the transcriptional regulation of the hypothalamic-pituitary-testicular axis in holstein-friesian bull calves
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cd2b45de272242b3a9120e2137bc196f
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Effect of Early Calf-Hood Nutrition on the Transcriptional Regulation of the Hypothalamic-Pituitary-Testicular axis in Holstein-Friesian Bull Calves

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