Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

Restoring oxygenation in hypoxic tumors might lead to favorable oncological outcome of patients if combined with standard multimodal therapy regimens. Here the authors report a phase Ib clinical trial of anti-hypoxic myo-inositol trispyrophosphate (ITPP) in hepato-pancreato-biliary neoplasms.

Guardado en:

Detalles Bibliográficos
Autores principales:	Marcel A. Schneider, Michael Linecker, Ralph Fritsch, Urs J. Muehlematter, Daniel Stocker, Bernhard Pestalozzi, Panagiotis Samaras, Alexander Jetter, Philipp Kron, Henrik Petrowsky, Claude Nicolau, Jean-Marie Lehn, Bostjan Humar, Rolf Graf, Pierre-Alain Clavien, Perparim Limani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd2ec9ef8ede4523a0cca213868f4458
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd2ec9ef8ede4523a0cca213868f4458
record_format	dspace
spelling	oai:doaj.org-article:cd2ec9ef8ede4523a0cca213868f44582021-12-02T16:05:51ZPhase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors10.1038/s41467-021-24069-w2041-1723https://doaj.org/article/cd2ec9ef8ede4523a0cca213868f44582021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24069-whttps://doaj.org/toc/2041-1723Restoring oxygenation in hypoxic tumors might lead to favorable oncological outcome of patients if combined with standard multimodal therapy regimens. Here the authors report a phase Ib clinical trial of anti-hypoxic myo-inositol trispyrophosphate (ITPP) in hepato-pancreato-biliary neoplasms.Marcel A. SchneiderMichael LineckerRalph FritschUrs J. MuehlematterDaniel StockerBernhard PestalozziPanagiotis SamarasAlexander JetterPhilipp KronHenrik PetrowskyClaude NicolauJean-Marie LehnBostjan HumarRolf GrafPierre-Alain ClavienPerparim LimaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marcel A. Schneider Michael Linecker Ralph Fritsch Urs J. Muehlematter Daniel Stocker Bernhard Pestalozzi Panagiotis Samaras Alexander Jetter Philipp Kron Henrik Petrowsky Claude Nicolau Jean-Marie Lehn Bostjan Humar Rolf Graf Pierre-Alain Clavien Perparim Limani Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
description	Restoring oxygenation in hypoxic tumors might lead to favorable oncological outcome of patients if combined with standard multimodal therapy regimens. Here the authors report a phase Ib clinical trial of anti-hypoxic myo-inositol trispyrophosphate (ITPP) in hepato-pancreato-biliary neoplasms.
format	article
author	Marcel A. Schneider Michael Linecker Ralph Fritsch Urs J. Muehlematter Daniel Stocker Bernhard Pestalozzi Panagiotis Samaras Alexander Jetter Philipp Kron Henrik Petrowsky Claude Nicolau Jean-Marie Lehn Bostjan Humar Rolf Graf Pierre-Alain Clavien Perparim Limani
author_facet	Marcel A. Schneider Michael Linecker Ralph Fritsch Urs J. Muehlematter Daniel Stocker Bernhard Pestalozzi Panagiotis Samaras Alexander Jetter Philipp Kron Henrik Petrowsky Claude Nicolau Jean-Marie Lehn Bostjan Humar Rolf Graf Pierre-Alain Clavien Perparim Limani
author_sort	Marcel A. Schneider
title	Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
title_short	Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
title_full	Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
title_fullStr	Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
title_full_unstemmed	Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
title_sort	phase ib dose-escalation study of the hypoxia-modifier myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd2ec9ef8ede4523a0cca213868f4458
work_keys_str_mv	AT marcelaschneider phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT michaellinecker phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT ralphfritsch phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT ursjmuehlematter phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT danielstocker phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT bernhardpestalozzi phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT panagiotissamaras phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT alexanderjetter phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT philippkron phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT henrikpetrowsky phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT claudenicolau phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT jeanmarielehn phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT bostjanhumar phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT rolfgraf phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT pierrealainclavien phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors AT perparimlimani phaseibdoseescalationstudyofthehypoxiamodifiermyoinositoltrispyrophosphateinpatientswithhepatopancreatobiliarytumors
_version_	1718385176510201856

Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

Ejemplares similares