Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Inmaculada Tasset1, José Peña2, Ignacio Jimena2, Montserrat Feijóo1, María del Carmen Muñoz1, Pedro Montilla1, Isaac Túnez11Departamento de Bioquímica y Biología Molecular, Faculta...

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Autores principales: Inmaculada Tasset, José Peña, Ignacio Jimena, Montserrat Feijóo, María del Carmen Muñoz, et al
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2008
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/cd2f94251d6844d0b360050787bc088d
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spelling oai:doaj.org-article:cd2f94251d6844d0b360050787bc088d2021-12-02T02:10:16ZEffect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats1176-63281178-2021https://doaj.org/article/cd2f94251d6844d0b360050787bc088d2008-04-01T00:00:00Zhttp://www.dovepress.com/effect-of-17beta-estradiol-on-olfactory-bulbectomy-induced-oxidative-s-a1022https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Inmaculada Tasset1, José Peña2, Ignacio Jimena2, Montserrat Feijóo1, María del Carmen Muñoz1, Pedro Montilla1, Isaac Túnez11Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain; 2Departamento de Ciencias Morfológicas, Sección de Histología, Facultad de Medicina, Universidad de Córdoba, SpainAbstract: The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.Keywords: behavioral, depression, 17β-estradiol, oxidative stress Inmaculada TassetJosé PeñaIgnacio JimenaMontserrat FeijóoMaría del Carmen Muñozet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 2, Pp 441-449 (2008)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Inmaculada Tasset
José Peña
Ignacio Jimena
Montserrat Feijóo
María del Carmen Muñoz
et al
Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
description Inmaculada Tasset1, José Peña2, Ignacio Jimena2, Montserrat Feijóo1, María del Carmen Muñoz1, Pedro Montilla1, Isaac Túnez11Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain; 2Departamento de Ciencias Morfológicas, Sección de Histología, Facultad de Medicina, Universidad de Córdoba, SpainAbstract: The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.Keywords: behavioral, depression, 17β-estradiol, oxidative stress
format article
author Inmaculada Tasset
José Peña
Ignacio Jimena
Montserrat Feijóo
María del Carmen Muñoz
et al
author_facet Inmaculada Tasset
José Peña
Ignacio Jimena
Montserrat Feijóo
María del Carmen Muñoz
et al
author_sort Inmaculada Tasset
title Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_short Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_full Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_fullStr Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_full_unstemmed Effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
title_sort effect of 17β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/cd2f94251d6844d0b360050787bc088d
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