Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Introduction: Tuberculosis (TB) is a major infectious disease that seriously endangers human health and female reproduction. In our previous study, 10.4% of infertile patients preparing for In vitro fertilization and embryo transfer (IVF-ET) had prior pulmonary TB (PTB) as detected on chest X-ray (C...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoyan Gai, Hongbin Chi, Lin Zeng, Wenli Cao, Lixue Chen, Chen Zhang, Rong Li, Yongchang Sun, Jie Qiao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	interferon-gamma release assay tuberculosis IVF-ET pregnancy outcome infertility Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd33a8bb955e4b7594e9c51d5cc34b6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd33a8bb955e4b7594e9c51d5cc34b6e
record_format	dspace
spelling	oai:doaj.org-article:cd33a8bb955e4b7594e9c51d5cc34b6e2021-11-16T04:44:51ZImpact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study2296-858X10.3389/fmed.2021.749410https://doaj.org/article/cd33a8bb955e4b7594e9c51d5cc34b6e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.749410/fullhttps://doaj.org/toc/2296-858XIntroduction: Tuberculosis (TB) is a major infectious disease that seriously endangers human health and female reproduction. In our previous study, 10.4% of infertile patients preparing for In vitro fertilization and embryo transfer (IVF-ET) had prior pulmonary TB (PTB) as detected on chest X-ray (CXR) screening. Among them, 81.8% did not receive anti-TB treatment. It remains unclear whether infertile women with untreated prior PTB have latent TB infection (LTBI) and whether LTBI affects IVF-ET outcomes. In this study, we aim to analyze the relationship between LTBI and pregnancy outcomes following IVF-ET in patients with untreated prior PTB.Methods and Analysis: We designed a prospective cohort study of 1,200 infertile women with CXR findings suggestive of old-healed untreated TB, who are preparing for IVF-ET. Patients with a history of active TB and anti-TB treatment will be excluded. Interferon-gamma release assay (IGRA) will be used in patients with CXR findings suggestive of old-healed untreated TB to construct a cohort of IGRA-positive and IGRA-negative patients. Participants will undergo IVF-ET. General information, including age, body mass index, infertility causes, and controlled ovarian hyperstimulation protocol, will be recorded. Participants will be followed up during pregnancy. The primary outcome is live birth. Secondary outcomes include the numbers of retrieved oocytes, high-quality embryo rate, clinical pregnancy, number of active TB cases during pregnancy, and miscarriage.Ethics and Dissemination: The study was approved by the Ethics Committee of Peking University Third Hospital [approval number (2020)218-01; approval date: June 19, 2020]. The research results will be disseminated through scientific/medical conferences and published in academic journals.Trial Registration:ClinicalTrials.gov; identifier: NCT04443283.Xiaoyan GaiHongbin ChiLin ZengWenli CaoLixue ChenChen ZhangRong LiYongchang SunJie QiaoFrontiers Media S.A.articleinterferon-gamma release assaytuberculosisIVF-ETpregnancy outcomeinfertilityMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interferon-gamma release assay tuberculosis IVF-ET pregnancy outcome infertility Medicine (General) R5-920
spellingShingle	interferon-gamma release assay tuberculosis IVF-ET pregnancy outcome infertility Medicine (General) R5-920 Xiaoyan Gai Hongbin Chi Lin Zeng Wenli Cao Lixue Chen Chen Zhang Rong Li Yongchang Sun Jie Qiao Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
description	Introduction: Tuberculosis (TB) is a major infectious disease that seriously endangers human health and female reproduction. In our previous study, 10.4% of infertile patients preparing for In vitro fertilization and embryo transfer (IVF-ET) had prior pulmonary TB (PTB) as detected on chest X-ray (CXR) screening. Among them, 81.8% did not receive anti-TB treatment. It remains unclear whether infertile women with untreated prior PTB have latent TB infection (LTBI) and whether LTBI affects IVF-ET outcomes. In this study, we aim to analyze the relationship between LTBI and pregnancy outcomes following IVF-ET in patients with untreated prior PTB.Methods and Analysis: We designed a prospective cohort study of 1,200 infertile women with CXR findings suggestive of old-healed untreated TB, who are preparing for IVF-ET. Patients with a history of active TB and anti-TB treatment will be excluded. Interferon-gamma release assay (IGRA) will be used in patients with CXR findings suggestive of old-healed untreated TB to construct a cohort of IGRA-positive and IGRA-negative patients. Participants will undergo IVF-ET. General information, including age, body mass index, infertility causes, and controlled ovarian hyperstimulation protocol, will be recorded. Participants will be followed up during pregnancy. The primary outcome is live birth. Secondary outcomes include the numbers of retrieved oocytes, high-quality embryo rate, clinical pregnancy, number of active TB cases during pregnancy, and miscarriage.Ethics and Dissemination: The study was approved by the Ethics Committee of Peking University Third Hospital [approval number (2020)218-01; approval date: June 19, 2020]. The research results will be disseminated through scientific/medical conferences and published in academic journals.Trial Registration:ClinicalTrials.gov; identifier: NCT04443283.
format	article
author	Xiaoyan Gai Hongbin Chi Lin Zeng Wenli Cao Lixue Chen Chen Zhang Rong Li Yongchang Sun Jie Qiao
author_facet	Xiaoyan Gai Hongbin Chi Lin Zeng Wenli Cao Lixue Chen Chen Zhang Rong Li Yongchang Sun Jie Qiao
author_sort	Xiaoyan Gai
title	Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
title_short	Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
title_full	Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
title_fullStr	Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
title_full_unstemmed	Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study
title_sort	impact of positive interferon-gamma release assay on ivf-et pregnancy outcomes in infertile patients with untreated prior tuberculosis: a prospective cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cd33a8bb955e4b7594e9c51d5cc34b6e
work_keys_str_mv	AT xiaoyangai impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT hongbinchi impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT linzeng impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT wenlicao impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT lixuechen impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT chenzhang impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT rongli impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT yongchangsun impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy AT jieqiao impactofpositiveinterferongammareleaseassayonivfetpregnancyoutcomesininfertilepatientswithuntreatedpriortuberculosisaprospectivecohortstudy
_version_	1718426753148387328

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Ejemplares similares