Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection.
T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are predictive of the rate of progression towards AIDS. We evaluated whether the inflammatory profile during primary HIV-1 infection is predictive of the virological and immunological set-points and of d...
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2012
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oai:doaj.org-article:cd33b5fb314b4c41996799b24ca1a0d42021-11-18T08:13:29ZAcute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection.1932-620310.1371/journal.pone.0046143https://doaj.org/article/cd33b5fb314b4c41996799b24ca1a0d42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23056251/?tool=EBIhttps://doaj.org/toc/1932-6203T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are predictive of the rate of progression towards AIDS. We evaluated whether the inflammatory profile during primary HIV-1 infection is predictive of the virological and immunological set-points and of disease progression. We quantified 28 plasma proteins during acute and post-acute HIV-1 infection in individuals with known disease progression profiles. Forty-six untreated patients, enrolled during primary HIV-1 infection, were categorized into rapid progressors, progressors and slow progressors according to their spontaneous progression profile over 42 months of follow-up. Already during primary infection, rapid progressors showed a higher number of increased plasma proteins than progressors or slow progressors. The plasma levels of TGF-β1 and IL-18 in primary HIV-1 infection were both positively associated with T cell activation level at set-point (6 months after acute infection) and together able to predict 74% of the T cell activation variation at set-point. Plasma IP-10 was positively and negatively associated with, respectively, T cell activation and CD4(+) T cell counts at set-point and capable to predict 30% of the CD4(+) T cell count variation at set-point. Moreover, plasma IP-10 levels during primary infection were predictive of rapid progression. In primary infection, IP-10 was an even better predictor of rapid disease progression than viremia or CD4(+) T cell levels at this time point. The superior predictive capacity of IP-10 was confirmed in an independent group of 88 HIV-1 infected individuals. Altogether, this study shows that the inflammatory profile in primary HIV-1 infection is associated with T cell activation levels and CD4(+) T cell counts at set-point. Plasma IP-10 levels were of strong predictive value for rapid disease progression. The data suggest IP-10 being an earlier marker of disease progression than CD4(+) T cell counts or viremia levels.Anne-Sophie LiovatMarie-Anne Rey-CuilléCamille LécurouxBéatrice JacquelinIsabelle GiraultGaël PetitjeanYasmine ZitounAlain VenetFrançoise Barré-SinoussiPierre LebonLaurence MeyerMartine SinetMichaela Müller-TrutwinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46143 (2012) |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Anne-Sophie Liovat Marie-Anne Rey-Cuillé Camille Lécuroux Béatrice Jacquelin Isabelle Girault Gaël Petitjean Yasmine Zitoun Alain Venet Françoise Barré-Sinoussi Pierre Lebon Laurence Meyer Martine Sinet Michaela Müller-Trutwin Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| description |
T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are predictive of the rate of progression towards AIDS. We evaluated whether the inflammatory profile during primary HIV-1 infection is predictive of the virological and immunological set-points and of disease progression. We quantified 28 plasma proteins during acute and post-acute HIV-1 infection in individuals with known disease progression profiles. Forty-six untreated patients, enrolled during primary HIV-1 infection, were categorized into rapid progressors, progressors and slow progressors according to their spontaneous progression profile over 42 months of follow-up. Already during primary infection, rapid progressors showed a higher number of increased plasma proteins than progressors or slow progressors. The plasma levels of TGF-β1 and IL-18 in primary HIV-1 infection were both positively associated with T cell activation level at set-point (6 months after acute infection) and together able to predict 74% of the T cell activation variation at set-point. Plasma IP-10 was positively and negatively associated with, respectively, T cell activation and CD4(+) T cell counts at set-point and capable to predict 30% of the CD4(+) T cell count variation at set-point. Moreover, plasma IP-10 levels during primary infection were predictive of rapid progression. In primary infection, IP-10 was an even better predictor of rapid disease progression than viremia or CD4(+) T cell levels at this time point. The superior predictive capacity of IP-10 was confirmed in an independent group of 88 HIV-1 infected individuals. Altogether, this study shows that the inflammatory profile in primary HIV-1 infection is associated with T cell activation levels and CD4(+) T cell counts at set-point. Plasma IP-10 levels were of strong predictive value for rapid disease progression. The data suggest IP-10 being an earlier marker of disease progression than CD4(+) T cell counts or viremia levels. |
| format |
article |
| author |
Anne-Sophie Liovat Marie-Anne Rey-Cuillé Camille Lécuroux Béatrice Jacquelin Isabelle Girault Gaël Petitjean Yasmine Zitoun Alain Venet Françoise Barré-Sinoussi Pierre Lebon Laurence Meyer Martine Sinet Michaela Müller-Trutwin |
| author_facet |
Anne-Sophie Liovat Marie-Anne Rey-Cuillé Camille Lécuroux Béatrice Jacquelin Isabelle Girault Gaël Petitjean Yasmine Zitoun Alain Venet Françoise Barré-Sinoussi Pierre Lebon Laurence Meyer Martine Sinet Michaela Müller-Trutwin |
| author_sort |
Anne-Sophie Liovat |
| title |
Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| title_short |
Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| title_full |
Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| title_fullStr |
Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| title_full_unstemmed |
Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. |
| title_sort |
acute plasma biomarkers of t cell activation set-point levels and of disease progression in hiv-1 infection. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/cd33b5fb314b4c41996799b24ca1a0d4 |
| work_keys_str_mv |
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