Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease

Abstract Telomere length has been linked to the prevalence and progression of metabolic disease. However, clinical implications of telomere length in biopsy-proven non-alcoholic fatty liver disease (NAFLD) patients remain unclear. Therefore, this study aimed to investigate the association of telomer...

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Autores principales:	Hee Kyung Shin, Jeong Hwan Park, Jung Hwan Yu, Young-Joo Jin, Young Ju Suh, Jin-Woo Lee, Won Kim, The Korean Nonalcoholic Fatty Liver Study Group (KNSG)
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd398ea0a0b2479295a9ed5036478136
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spelling	oai:doaj.org-article:cd398ea0a0b2479295a9ed50364781362021-12-02T17:19:14ZAssociation between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease10.1038/s41598-021-97385-22045-2322https://doaj.org/article/cd398ea0a0b2479295a9ed50364781362021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97385-2https://doaj.org/toc/2045-2322Abstract Telomere length has been linked to the prevalence and progression of metabolic disease. However, clinical implications of telomere length in biopsy-proven non-alcoholic fatty liver disease (NAFLD) patients remain unclear. Therefore, this study aimed to investigate the association of telomere length with the histological severity of NAFLD. The cross-sectional data derived from the prospectively enrolled Boramae NAFLD registry (n = 91) were analyzed. The liver tissues and clinical information were obtained from both NAFLD patients and non-NAFLD subjects. Binary logistic regression was performed to identify the independent association between telomere length and the histological severity of NAFLD. A total of 83 subjects with or without biopsy-proven NAFLD were included for analysis: non-NAFLD in 23 (27.7%), non-alcoholic fatty liver in 15 (18.1%), and non-alcoholic steatohepatitis (NASH) in 45 (54.2%). Telomere length measured from liver tissues showed a strong negative correlation (p < 0.001) with age, regardless of NAFLD status. Therefore, telomere length was corrected for age. Age-adjusted telomere length than decreased gradually with an increasing severity of fibrosis in patients with NAFLD (p < 0.028). In multivariate analysis, age-adjusted telomere length (odds ratio [OR] 0.59; 95% CI 0.37–0.92; p = 0.019) and high-density lipoprotein cholesterol (OR 0.94; 95% CI 0.80–0.99; p = 0.039) were independently associated with significant fibrosis. The age-adjusted telomere length tends to decrease along with the fibrosis stage of NAFLD. In particular, among the histological components of NAFLD, fibrosis severity seems to be related to telomere length in the liver.Hee Kyung ShinJeong Hwan ParkJung Hwan YuYoung-Joo JinYoung Ju SuhJin-Woo LeeWon KimThe Korean Nonalcoholic Fatty Liver Study Group (KNSG)Nature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hee Kyung Shin Jeong Hwan Park Jung Hwan Yu Young-Joo Jin Young Ju Suh Jin-Woo Lee Won Kim The Korean Nonalcoholic Fatty Liver Study Group (KNSG) Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
description	Abstract Telomere length has been linked to the prevalence and progression of metabolic disease. However, clinical implications of telomere length in biopsy-proven non-alcoholic fatty liver disease (NAFLD) patients remain unclear. Therefore, this study aimed to investigate the association of telomere length with the histological severity of NAFLD. The cross-sectional data derived from the prospectively enrolled Boramae NAFLD registry (n = 91) were analyzed. The liver tissues and clinical information were obtained from both NAFLD patients and non-NAFLD subjects. Binary logistic regression was performed to identify the independent association between telomere length and the histological severity of NAFLD. A total of 83 subjects with or without biopsy-proven NAFLD were included for analysis: non-NAFLD in 23 (27.7%), non-alcoholic fatty liver in 15 (18.1%), and non-alcoholic steatohepatitis (NASH) in 45 (54.2%). Telomere length measured from liver tissues showed a strong negative correlation (p < 0.001) with age, regardless of NAFLD status. Therefore, telomere length was corrected for age. Age-adjusted telomere length than decreased gradually with an increasing severity of fibrosis in patients with NAFLD (p < 0.028). In multivariate analysis, age-adjusted telomere length (odds ratio [OR] 0.59; 95% CI 0.37–0.92; p = 0.019) and high-density lipoprotein cholesterol (OR 0.94; 95% CI 0.80–0.99; p = 0.039) were independently associated with significant fibrosis. The age-adjusted telomere length tends to decrease along with the fibrosis stage of NAFLD. In particular, among the histological components of NAFLD, fibrosis severity seems to be related to telomere length in the liver.
format	article
author	Hee Kyung Shin Jeong Hwan Park Jung Hwan Yu Young-Joo Jin Young Ju Suh Jin-Woo Lee Won Kim The Korean Nonalcoholic Fatty Liver Study Group (KNSG)
author_facet	Hee Kyung Shin Jeong Hwan Park Jung Hwan Yu Young-Joo Jin Young Ju Suh Jin-Woo Lee Won Kim The Korean Nonalcoholic Fatty Liver Study Group (KNSG)
author_sort	Hee Kyung Shin
title	Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
title_short	Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
title_full	Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
title_fullStr	Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
title_full_unstemmed	Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
title_sort	association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd398ea0a0b2479295a9ed5036478136
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Association between telomere length and hepatic fibrosis in non-alcoholic fatty liver disease

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