Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Abstract The association between thiazide use and fracture risk is still controversial. We conducted an updated meta-analysis on the association between thiazide use and fracture risk. We systematically searched PubMed, Embase, and Cochrane library databases for all types of human studies, including...

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Autores principales:	Tesfaye Getachew Charkos, Yawen Liu, Lina Jin, Shuman Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd3b0cb0624e49b898929b830ab61cb9
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spelling	oai:doaj.org-article:cd3b0cb0624e49b898929b830ab61cb92021-12-02T13:35:03ZThiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis10.1038/s41598-019-56108-42045-2322https://doaj.org/article/cd3b0cb0624e49b898929b830ab61cb92019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56108-4https://doaj.org/toc/2045-2322Abstract The association between thiazide use and fracture risk is still controversial. We conducted an updated meta-analysis on the association between thiazide use and fracture risk. We systematically searched PubMed, Embase, and Cochrane library databases for all types of human studies, including observational and experimental studies that were published up until July 2019. We also manually searched the reference lists of relevant studies. The pooled relative risks (RRs) with 95% credible interval (CrI) were calculated using a Bayesian hierarchical random effect model. A total of 19 case-control (N = 496,568 subjects) and 21 cohort studies (N = 4,418,602 subjects) were included in this meta-analysis. The pooled RR for fractures associated with thiazide use was 0.87 (95% CrI: 0.70–0.99) in case-control and 0.95 (95% CrI: 0.85–1.08) in cohort studies. The probabilities that thiazide use reduces any fracture risk by more than 0% were 93% in case-control studies and 72% in cohort studies. Significant heterogeneity was found for both case-control (p < 0.001, I2 = 75%) and cohort studies (p < 0.001, I2 = 97.2%). Thiazide use was associated with reduced fracture risk in case-control studies, but not in cohort studies. The associations demonstrated in case-control studies might be driven by inherent biases, such as selection bias and recall bias. Thus, thiazide use may not be a protective factor for fractures.Tesfaye Getachew CharkosYawen LiuLina JinShuman YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tesfaye Getachew Charkos Yawen Liu Lina Jin Shuman Yang Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
description	Abstract The association between thiazide use and fracture risk is still controversial. We conducted an updated meta-analysis on the association between thiazide use and fracture risk. We systematically searched PubMed, Embase, and Cochrane library databases for all types of human studies, including observational and experimental studies that were published up until July 2019. We also manually searched the reference lists of relevant studies. The pooled relative risks (RRs) with 95% credible interval (CrI) were calculated using a Bayesian hierarchical random effect model. A total of 19 case-control (N = 496,568 subjects) and 21 cohort studies (N = 4,418,602 subjects) were included in this meta-analysis. The pooled RR for fractures associated with thiazide use was 0.87 (95% CrI: 0.70–0.99) in case-control and 0.95 (95% CrI: 0.85–1.08) in cohort studies. The probabilities that thiazide use reduces any fracture risk by more than 0% were 93% in case-control studies and 72% in cohort studies. Significant heterogeneity was found for both case-control (p < 0.001, I2 = 75%) and cohort studies (p < 0.001, I2 = 97.2%). Thiazide use was associated with reduced fracture risk in case-control studies, but not in cohort studies. The associations demonstrated in case-control studies might be driven by inherent biases, such as selection bias and recall bias. Thus, thiazide use may not be a protective factor for fractures.
format	article
author	Tesfaye Getachew Charkos Yawen Liu Lina Jin Shuman Yang
author_facet	Tesfaye Getachew Charkos Yawen Liu Lina Jin Shuman Yang
author_sort	Tesfaye Getachew Charkos
title	Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
title_short	Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
title_full	Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
title_fullStr	Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
title_full_unstemmed	Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis
title_sort	thiazide use and fracture risk: an updated bayesian meta-analysis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cd3b0cb0624e49b898929b830ab61cb9
work_keys_str_mv	AT tesfayegetachewcharkos thiazideuseandfractureriskanupdatedbayesianmetaanalysis AT yawenliu thiazideuseandfractureriskanupdatedbayesianmetaanalysis AT linajin thiazideuseandfractureriskanupdatedbayesianmetaanalysis AT shumanyang thiazideuseandfractureriskanupdatedbayesianmetaanalysis
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Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

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