Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.

<h4>Background and objectives</h4>Although association between respiratory syncytial virus infection and later asthma development has been established, little is known about the role of other respiratory viruses. Rhinovirus was considered a mild pathogen of the upper respiratory tract bu...

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Autores principales:	Cristina O'Callaghan-Gordo, Quique Bassat, Núria Díez-Padrisa, Luis Morais, Sónia Machevo, Tacilta Nhampossa, Llorenç Quintó, Pedro L Alonso, Anna Roca
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd3b9aee52d0453c817596d1065a90a5
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spelling	oai:doaj.org-article:cd3b9aee52d0453c817596d1065a90a52021-11-18T09:01:52ZLower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.1932-620310.1371/journal.pone.0069370https://doaj.org/article/cd3b9aee52d0453c817596d1065a90a52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23935997/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objectives</h4>Although association between respiratory syncytial virus infection and later asthma development has been established, little is known about the role of other respiratory viruses. Rhinovirus was considered a mild pathogen of the upper respiratory tract but current evidence suggests that rhinovirus is highly prevalent among children with lower respiratory tract infections (LRTI). The aim of the study was to evaluate whether LRTI hospitalization associated with rhinovirus during infancy was associated with an increased risk of wheezing - a proxy measure of asthma - during childhood.<h4>Methods</h4>During a 12 months period, all infants <1 year admitted to Manhiça District Hospital with symptoms of LRTI who survived the LRTI episode, were enrolled in the study cohort. Nasopharyngeal aspirates were collected on admission for viral determination and study infants were classified according to presence or not of rhinovirus. The study cohort was passively followed-up at the Manhiça District Hospital for up to 4 years and 9 months to evaluate the association between LRTI associated with rhinovirus in infancy and wheezing during childhood.<h4>Findings and conclusions</h4>A total of 220 infants entered the cohort; 25% of them had rhinovirus detected during the LRTI episode as opposed to 75% who tested negative for rhinovirus. After adjusting for sex and age and HIV infection at recruitment, infants hospitalized with LRTI associated with rhinovirus had higher incidence of subsequent visits with wheezing within the year following hospitalization [Rate ratio=1.68, (95% confidence interval=1.02-2.75); Wald test p-value = 0.039]. No evidence of increased incidence rate of visits with wheezing was observed for the remaining follow-up period. Our data suggest a short term increased risk of wheezing after an initial episode of LRTI with RV.Cristina O'Callaghan-GordoQuique BassatNúria Díez-PadrisaLuis MoraisSónia MachevoTacilta NhampossaLlorenç QuintóPedro L AlonsoAnna RocaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69370 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristina O'Callaghan-Gordo Quique Bassat Núria Díez-Padrisa Luis Morais Sónia Machevo Tacilta Nhampossa Llorenç Quintó Pedro L Alonso Anna Roca Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
description	<h4>Background and objectives</h4>Although association between respiratory syncytial virus infection and later asthma development has been established, little is known about the role of other respiratory viruses. Rhinovirus was considered a mild pathogen of the upper respiratory tract but current evidence suggests that rhinovirus is highly prevalent among children with lower respiratory tract infections (LRTI). The aim of the study was to evaluate whether LRTI hospitalization associated with rhinovirus during infancy was associated with an increased risk of wheezing - a proxy measure of asthma - during childhood.<h4>Methods</h4>During a 12 months period, all infants <1 year admitted to Manhiça District Hospital with symptoms of LRTI who survived the LRTI episode, were enrolled in the study cohort. Nasopharyngeal aspirates were collected on admission for viral determination and study infants were classified according to presence or not of rhinovirus. The study cohort was passively followed-up at the Manhiça District Hospital for up to 4 years and 9 months to evaluate the association between LRTI associated with rhinovirus in infancy and wheezing during childhood.<h4>Findings and conclusions</h4>A total of 220 infants entered the cohort; 25% of them had rhinovirus detected during the LRTI episode as opposed to 75% who tested negative for rhinovirus. After adjusting for sex and age and HIV infection at recruitment, infants hospitalized with LRTI associated with rhinovirus had higher incidence of subsequent visits with wheezing within the year following hospitalization [Rate ratio=1.68, (95% confidence interval=1.02-2.75); Wald test p-value = 0.039]. No evidence of increased incidence rate of visits with wheezing was observed for the remaining follow-up period. Our data suggest a short term increased risk of wheezing after an initial episode of LRTI with RV.
format	article
author	Cristina O'Callaghan-Gordo Quique Bassat Núria Díez-Padrisa Luis Morais Sónia Machevo Tacilta Nhampossa Llorenç Quintó Pedro L Alonso Anna Roca
author_facet	Cristina O'Callaghan-Gordo Quique Bassat Núria Díez-Padrisa Luis Morais Sónia Machevo Tacilta Nhampossa Llorenç Quintó Pedro L Alonso Anna Roca
author_sort	Cristina O'Callaghan-Gordo
title	Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
title_short	Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
title_full	Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
title_fullStr	Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
title_full_unstemmed	Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.
title_sort	lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. a cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cd3b9aee52d0453c817596d1065a90a5
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Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study.

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