ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS

During last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mecha...

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Autor principal:	O. .A. Gankovskaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	inborn immunity toll-like receptors polimorphism pretermbirth urogenital infeсtion Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cd3c554a483b47848fc27adc86ceb445
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id	oai:doaj.org-article:cd3c554a483b47848fc27adc86ceb445
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spelling	oai:doaj.org-article:cd3c554a483b47848fc27adc86ceb4452021-11-18T08:03:37ZASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS1563-06252313-741X10.15789/1563-0625-2010-1-2-https://doaj.org/article/cd3c554a483b47848fc27adc86ceb4452014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/49https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDuring last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mechanisms with genetic factors in pregnant women were poorly studied. The aim of present study was to evaluate associations between the following SNPs: Arg677Trp, Arg753Gln of TLR2 gene, A2848G SNP of TLR9 gene, and frequencies of pre-term birth complicated by infections in Russian population of Moscow City. SNPs Arg677Trp, Arg753Gln in TLR2 gene have been studied in a clinical material by means of PCR-RFLP analysis, using AciI restrictase. A2848G polymorphic marker in TLR9 gene was assessed by real-time PCR, employing TaqMan probes. It has been shown, that Arg allele of Arg753Gln TLR2 gene was associated with urogenital infections. When studying A2848G polymorphism in TLR9 gene, the A Allele was associated with normal delivery, thus assuming the A2848G polymorphic marker as a protective one.O. .A. GankovskayaSPb RAACIarticleinborn immunitytoll-like receptorspolimorphismpretermbirthurogenital infeсtionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 87-94 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	inborn immunity toll-like receptors polimorphism pretermbirth urogenital infeсtion Immunologic diseases. Allergy RC581-607
spellingShingle	inborn immunity toll-like receptors polimorphism pretermbirth urogenital infeсtion Immunologic diseases. Allergy RC581-607 O. .A. Gankovskaya ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
description	During last years, a role of genetic factors in maturation of innate immunity functions was actively studied. It is known, that some SNP in TLR9 and TLR2 genes are known to be associated with development of infection in pregnancy. However, interrelations of various TLR-mediated anti-infectious mechanisms with genetic factors in pregnant women were poorly studied. The aim of present study was to evaluate associations between the following SNPs: Arg677Trp, Arg753Gln of TLR2 gene, A2848G SNP of TLR9 gene, and frequencies of pre-term birth complicated by infections in Russian population of Moscow City. SNPs Arg677Trp, Arg753Gln in TLR2 gene have been studied in a clinical material by means of PCR-RFLP analysis, using AciI restrictase. A2848G polymorphic marker in TLR9 gene was assessed by real-time PCR, employing TaqMan probes. It has been shown, that Arg allele of Arg753Gln TLR2 gene was associated with urogenital infections. When studying A2848G polymorphism in TLR9 gene, the A Allele was associated with normal delivery, thus assuming the A2848G polymorphic marker as a protective one.
format	article
author	O. .A. Gankovskaya
author_facet	O. .A. Gankovskaya
author_sort	O. .A. Gankovskaya
title	ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
title_short	ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
title_full	ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
title_fullStr	ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
title_full_unstemmed	ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS
title_sort	association studies between polymorphic markers tlr2 and tlr9, pre-term delivery and intrauterine infections
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cd3c554a483b47848fc27adc86ceb445
work_keys_str_mv	AT oagankovskaya associationstudiesbetweenpolymorphicmarkerstlr2andtlr9pretermdeliveryandintrauterineinfections
_version_	1718422568682127360

ASSOCIATION STUDIES BETWEEN POLYMORPHIC MARKERS TLR2 AND TLR9, PRE-TERM DELIVERY AND INTRAUTERINE INFECTIONS

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