Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts

Abstract Peripheral neuropathy is associated with substantial morbidity, but risk factors other than diabetes are largely uncharacterized. The aim of this study was to describe the prevalence and risk factors for peripheral neuropathy in adults with and without diabetes from two different population...

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Autores principales:	Caitlin W. Hicks, Dan Wang, B. Gwen Windham, Kunihiro Matsushita, Elizabeth Selvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd3cd9c9ffd846179510842c7b849a9f
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spelling	oai:doaj.org-article:cd3cd9c9ffd846179510842c7b849a9f2021-12-02T19:16:59ZPrevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts10.1038/s41598-021-98565-w2045-2322https://doaj.org/article/cd3cd9c9ffd846179510842c7b849a9f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98565-whttps://doaj.org/toc/2045-2322Abstract Peripheral neuropathy is associated with substantial morbidity, but risk factors other than diabetes are largely uncharacterized. The aim of this study was to describe the prevalence and risk factors for peripheral neuropathy in adults with and without diabetes from two different population-based studies in the US. We performed a cross-sectional analysis of 5200 black and white participants from NHANES (1999–2004, age 40–85 years) and 3362 black and white participants from the ARIC Study (2016–2017, age 70–89 years) who underwent monofilament testing for peripheral neuropathy using a shared protocol. We used logistic regression to quantify age, sex, and race-adjusted risk factor associations for peripheral neuropathy among middle-aged (40–69 years) and older (≥ 70 years) adults. The age, sex, and race-adjusted prevalence of peripheral neuropathy (decreased sensation on monofilament testing) was 10.4% for middle-aged adults in NHANES, 26.8% for older adults in NHANES, and 39.2% for older adults in ARIC. Diabetes was an important risk factor, but more strongly associated with peripheral neuropathy in middle-aged (OR ~ 5 for long-standing diabetes) compared to older adults (ORs ~ 1.5–2). Male sex (ORs ~ 2), black race (ORs ~ 1.3–1.5), and greater height (ORs ~ 1.5–3) were robust risk factors for peripheral neuropathy. Other risk factors included body mass index, education, and peripheral artery disease. The burden of peripheral neuropathy defined by abnormal monofilament testing among older adults is substantial, even among adults without diabetes. Studies are needed to understand the etiology and prognosis of peripheral neuropathy in the absence of diabetes.Caitlin W. HicksDan WangB. Gwen WindhamKunihiro MatsushitaElizabeth SelvinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caitlin W. Hicks Dan Wang B. Gwen Windham Kunihiro Matsushita Elizabeth Selvin Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
description	Abstract Peripheral neuropathy is associated with substantial morbidity, but risk factors other than diabetes are largely uncharacterized. The aim of this study was to describe the prevalence and risk factors for peripheral neuropathy in adults with and without diabetes from two different population-based studies in the US. We performed a cross-sectional analysis of 5200 black and white participants from NHANES (1999–2004, age 40–85 years) and 3362 black and white participants from the ARIC Study (2016–2017, age 70–89 years) who underwent monofilament testing for peripheral neuropathy using a shared protocol. We used logistic regression to quantify age, sex, and race-adjusted risk factor associations for peripheral neuropathy among middle-aged (40–69 years) and older (≥ 70 years) adults. The age, sex, and race-adjusted prevalence of peripheral neuropathy (decreased sensation on monofilament testing) was 10.4% for middle-aged adults in NHANES, 26.8% for older adults in NHANES, and 39.2% for older adults in ARIC. Diabetes was an important risk factor, but more strongly associated with peripheral neuropathy in middle-aged (OR ~ 5 for long-standing diabetes) compared to older adults (ORs ~ 1.5–2). Male sex (ORs ~ 2), black race (ORs ~ 1.3–1.5), and greater height (ORs ~ 1.5–3) were robust risk factors for peripheral neuropathy. Other risk factors included body mass index, education, and peripheral artery disease. The burden of peripheral neuropathy defined by abnormal monofilament testing among older adults is substantial, even among adults without diabetes. Studies are needed to understand the etiology and prognosis of peripheral neuropathy in the absence of diabetes.
format	article
author	Caitlin W. Hicks Dan Wang B. Gwen Windham Kunihiro Matsushita Elizabeth Selvin
author_facet	Caitlin W. Hicks Dan Wang B. Gwen Windham Kunihiro Matsushita Elizabeth Selvin
author_sort	Caitlin W. Hicks
title	Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
title_short	Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
title_full	Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
title_fullStr	Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
title_full_unstemmed	Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts
title_sort	prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two us cohorts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd3cd9c9ffd846179510842c7b849a9f
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Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts

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