De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution

Abstract Most high-risk neuroblastomas that initially respond to therapy will ultimately relapse. Currently, no curative treatment is available. Acquired genetic/molecular rearrangement in therapy-resistant cells contributes to tumor relapse. Recently, we identified significant RD3 loss in progressi...

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Autores principales: Dinesh Babu Somasundaram, Karthikeyan Subramanian, Sheeja Aravindan, Zhongxin Yu, Mohan Natarajan, Terence Herman, Natarajan Aravindan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cd3d4bfcdbd64518b851b5430f8b0c30
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