Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex

In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis. In doing so, they identified Gi-coupled receptors...

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Autores principales:	Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da068
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spelling	oai:doaj.org-article:cd48bdbae6944aca8dc5ad44ab6da0682021-12-02T18:24:52ZControl of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex10.1038/s42003-021-02188-w2399-3642https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da0682021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02188-whttps://doaj.org/toc/2399-3642In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis. In doing so, they identified Gi-coupled receptors in layer-5 pyramidal cells of the anterior cingulate cortex as potential therapeutic targets, which could pave the way for the development of treatments.Bastiaan van der VeenSampath K. T. KapanaiahKasyoka KilonzoPeter Steele-PerkinsMartin M. JendrykaStefanie SchulzBosiljka TasicZizhen YaoHongkui ZengThomas AkamJanet R. NicholsonBirgit LissWiebke NissenAnton PekcecDennis KätzelNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bastiaan van der Veen Sampath K. T. Kapanaiah Kasyoka Kilonzo Peter Steele-Perkins Martin M. Jendryka Stefanie Schulz Bosiljka Tasic Zizhen Yao Hongkui Zeng Thomas Akam Janet R. Nicholson Birgit Liss Wiebke Nissen Anton Pekcec Dennis Kätzel Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
description	In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis. In doing so, they identified Gi-coupled receptors in layer-5 pyramidal cells of the anterior cingulate cortex as potential therapeutic targets, which could pave the way for the development of treatments.
format	article
author	Bastiaan van der Veen Sampath K. T. Kapanaiah Kasyoka Kilonzo Peter Steele-Perkins Martin M. Jendryka Stefanie Schulz Bosiljka Tasic Zizhen Yao Hongkui Zeng Thomas Akam Janet R. Nicholson Birgit Liss Wiebke Nissen Anton Pekcec Dennis Kätzel
author_facet	Bastiaan van der Veen Sampath K. T. Kapanaiah Kasyoka Kilonzo Peter Steele-Perkins Martin M. Jendryka Stefanie Schulz Bosiljka Tasic Zizhen Yao Hongkui Zeng Thomas Akam Janet R. Nicholson Birgit Liss Wiebke Nissen Anton Pekcec Dennis Kätzel
author_sort	Bastiaan van der Veen
title	Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
title_short	Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
title_full	Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
title_fullStr	Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
title_full_unstemmed	Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
title_sort	control of impulsivity by gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da068
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Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex

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