Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis

Abstract We compared the efficacy and complications of core-needle biopsy (CNB) with those of fine-needle aspiration (FNA) in a large population of patients with initially detected thyroid nodules via a propensity score analysis. Outpatients with initially detected thyroid nodules, who had undergone...

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Autores principales:	Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Tae Yong Kim, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd4a43f9984d48b7841e73fcb00027bc
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spelling	oai:doaj.org-article:cd4a43f9984d48b7841e73fcb00027bc2021-12-02T11:40:14ZEfficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis10.1038/s41598-017-07924-z2045-2322https://doaj.org/article/cd4a43f9984d48b7841e73fcb00027bc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07924-zhttps://doaj.org/toc/2045-2322Abstract We compared the efficacy and complications of core-needle biopsy (CNB) with those of fine-needle aspiration (FNA) in a large population of patients with initially detected thyroid nodules via a propensity score analysis. Outpatients with initially detected thyroid nodules, who had undergone CNB or FNA between January 2013 and December 2013, were selected. This study included 4,822 thyroid nodules from 4,553 consecutive patients. Adjustments for significant differences in patients’ baseline characteristics were facilitated via propensity score analysis. Subgroup analyses were performed according to nodule sizes ≥ 1 cm. The non-diagnostic result rate, malignancy rate, complication rate, and diagnostic accuracy were compared. A 1:1 matching of 1,615 patients yielded no significant differences between two groups for any covariate. The non-diagnostic result rate was significantly lower in the core-needle biopsy group than in the fine-needle aspiration group (5.2% vs. 12.1%), while the malignancy rate (23.7% vs. 11.8%) and sensitivity (75.9% vs. 55.6%) were significantly higher. However, the specificities were similar (100% and 99.9%, respectively). Propensity score and subgroup analyses showed similar results. The complication rate was similar between groups in matched cohorts. CNB is a promising and safe diagnostic tool for patients with initially detected thyroid nodules.Chong Hyun SuhJung Hwan BaekYoung Jun ChoiTae Yong KimTae Yon SungDong Eun SongJeong Hyun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chong Hyun Suh Jung Hwan Baek Young Jun Choi Tae Yong Kim Tae Yon Sung Dong Eun Song Jeong Hyun Lee Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
description	Abstract We compared the efficacy and complications of core-needle biopsy (CNB) with those of fine-needle aspiration (FNA) in a large population of patients with initially detected thyroid nodules via a propensity score analysis. Outpatients with initially detected thyroid nodules, who had undergone CNB or FNA between January 2013 and December 2013, were selected. This study included 4,822 thyroid nodules from 4,553 consecutive patients. Adjustments for significant differences in patients’ baseline characteristics were facilitated via propensity score analysis. Subgroup analyses were performed according to nodule sizes ≥ 1 cm. The non-diagnostic result rate, malignancy rate, complication rate, and diagnostic accuracy were compared. A 1:1 matching of 1,615 patients yielded no significant differences between two groups for any covariate. The non-diagnostic result rate was significantly lower in the core-needle biopsy group than in the fine-needle aspiration group (5.2% vs. 12.1%), while the malignancy rate (23.7% vs. 11.8%) and sensitivity (75.9% vs. 55.6%) were significantly higher. However, the specificities were similar (100% and 99.9%, respectively). Propensity score and subgroup analyses showed similar results. The complication rate was similar between groups in matched cohorts. CNB is a promising and safe diagnostic tool for patients with initially detected thyroid nodules.
format	article
author	Chong Hyun Suh Jung Hwan Baek Young Jun Choi Tae Yong Kim Tae Yon Sung Dong Eun Song Jeong Hyun Lee
author_facet	Chong Hyun Suh Jung Hwan Baek Young Jun Choi Tae Yong Kim Tae Yon Sung Dong Eun Song Jeong Hyun Lee
author_sort	Chong Hyun Suh
title	Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
title_short	Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
title_full	Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
title_fullStr	Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
title_full_unstemmed	Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
title_sort	efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cd4a43f9984d48b7841e73fcb00027bc
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Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis

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