Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults

Abstract Objective Salivary cortisol and cortisone are used as biomarkers of physiological stress. Careful sampling of saliva for profiling of awakening response and the diurnal slope can be challenging in free-living environments, and validated sampling protocols are lacking. Therefore, we investig...

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Autores principales:	Sarah Overgaard Sørensen, Jesper Pedersen, Martin G. Rasmussen, Peter L. Kristensen, Anders Grøntved
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Physiological stress Saliva Cortisol Cortisone Feasibility Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/cd5007df462b4d728dcb6d774cd385a2
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spelling	oai:doaj.org-article:cd5007df462b4d728dcb6d774cd385a22021-11-08T10:58:39ZFeasibility of home-based sampling of salivary cortisol and cortisone in healthy adults10.1186/s13104-021-05820-41756-0500https://doaj.org/article/cd5007df462b4d728dcb6d774cd385a22021-11-01T00:00:00Zhttps://doi.org/10.1186/s13104-021-05820-4https://doaj.org/toc/1756-0500Abstract Objective Salivary cortisol and cortisone are used as biomarkers of physiological stress. Careful sampling of saliva for profiling of awakening response and the diurnal slope can be challenging in free-living environments, and validated sampling protocols are lacking. Therefore, we investigated (1) the level of compliance to a three-day home-based salivary sampling protocol, and (2) the within subject day-to-day variability of cortisol and cortisone outcomes and the required measuring days to obtain high reproducibility. Results Nineteen healthy adults (mean age: 42, 50% females) participated. Participants collected in total 434 salivary samples out of 456 scheduled (four samples per day over three consecutive days at two time points). We found high level of compliance to the proposed free-living salivary sampling protocol with 18 (95%) and 16 (84%) participants being compliant to numbers and timing of samples, respectively. The area under the curve for the morning salivary samples and peak-to-bed slope had moderate reproducibility for cortisol and cortisone (intraclass correlation coefficient: 0.51–0.68, and mean coefficient of variation: 14.7%-75.3%). Three-to-four measuring days were required for high reproducibility of the area under the curve for the morning salivary samples and peak-to-bed slope using this free-living salivary sampling protocol. Trial registration Clinical trial registered with www.clinicaltrials.gov (NCT03788525).Sarah Overgaard SørensenJesper PedersenMartin G. RasmussenPeter L. KristensenAnders GrøntvedBMCarticlePhysiological stressSalivaCortisolCortisoneFeasibilityMedicineRBiology (General)QH301-705.5Science (General)Q1-390ENBMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physiological stress Saliva Cortisol Cortisone Feasibility Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
spellingShingle	Physiological stress Saliva Cortisol Cortisone Feasibility Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 Sarah Overgaard Sørensen Jesper Pedersen Martin G. Rasmussen Peter L. Kristensen Anders Grøntved Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
description	Abstract Objective Salivary cortisol and cortisone are used as biomarkers of physiological stress. Careful sampling of saliva for profiling of awakening response and the diurnal slope can be challenging in free-living environments, and validated sampling protocols are lacking. Therefore, we investigated (1) the level of compliance to a three-day home-based salivary sampling protocol, and (2) the within subject day-to-day variability of cortisol and cortisone outcomes and the required measuring days to obtain high reproducibility. Results Nineteen healthy adults (mean age: 42, 50% females) participated. Participants collected in total 434 salivary samples out of 456 scheduled (four samples per day over three consecutive days at two time points). We found high level of compliance to the proposed free-living salivary sampling protocol with 18 (95%) and 16 (84%) participants being compliant to numbers and timing of samples, respectively. The area under the curve for the morning salivary samples and peak-to-bed slope had moderate reproducibility for cortisol and cortisone (intraclass correlation coefficient: 0.51–0.68, and mean coefficient of variation: 14.7%-75.3%). Three-to-four measuring days were required for high reproducibility of the area under the curve for the morning salivary samples and peak-to-bed slope using this free-living salivary sampling protocol. Trial registration Clinical trial registered with www.clinicaltrials.gov (NCT03788525).
format	article
author	Sarah Overgaard Sørensen Jesper Pedersen Martin G. Rasmussen Peter L. Kristensen Anders Grøntved
author_facet	Sarah Overgaard Sørensen Jesper Pedersen Martin G. Rasmussen Peter L. Kristensen Anders Grøntved
author_sort	Sarah Overgaard Sørensen
title	Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
title_short	Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
title_full	Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
title_fullStr	Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
title_full_unstemmed	Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
title_sort	feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cd5007df462b4d728dcb6d774cd385a2
work_keys_str_mv	AT sarahovergaardsørensen feasibilityofhomebasedsamplingofsalivarycortisolandcortisoneinhealthyadults AT jesperpedersen feasibilityofhomebasedsamplingofsalivarycortisolandcortisoneinhealthyadults AT martingrasmussen feasibilityofhomebasedsamplingofsalivarycortisolandcortisoneinhealthyadults AT peterlkristensen feasibilityofhomebasedsamplingofsalivarycortisolandcortisoneinhealthyadults AT andersgrøntved feasibilityofhomebasedsamplingofsalivarycortisolandcortisoneinhealthyadults
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Feasibility of home-based sampling of salivary cortisol and cortisone in healthy adults

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