Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection

Abstract Men’s sexual health can have significant effects on a man’s self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to the...

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Autores principales:	Eunryel Nam, Saejong Yoo, Hwi-Yool Kim, Young-Rok Kim, Yun Jung Heo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd52fff2541242c5bafefbf0039f3cf5
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spelling	oai:doaj.org-article:cd52fff2541242c5bafefbf0039f3cf52021-12-02T15:09:11ZTransdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection10.1038/s41598-018-25786-x2045-2322https://doaj.org/article/cd52fff2541242c5bafefbf0039f3cf52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25786-xhttps://doaj.org/toc/2045-2322Abstract Men’s sexual health can have significant effects on a man’s self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis. We optimize NE formation conditions including hydrophilic-lipophilic balance (HLB) and ratio of oil, water and surfactants. Then, by spreading NEs on penis skin of intact middle aged dogs, we verify medication effects and safety of the NEs in vivo. The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.Eunryel NamSaejong YooHwi-Yool KimYoung-Rok KimYun Jung HeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eunryel Nam Saejong Yoo Hwi-Yool Kim Young-Rok Kim Yun Jung Heo Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
description	Abstract Men’s sexual health can have significant effects on a man’s self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis. We optimize NE formation conditions including hydrophilic-lipophilic balance (HLB) and ratio of oil, water and surfactants. Then, by spreading NEs on penis skin of intact middle aged dogs, we verify medication effects and safety of the NEs in vivo. The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.
format	article
author	Eunryel Nam Saejong Yoo Hwi-Yool Kim Young-Rok Kim Yun Jung Heo
author_facet	Eunryel Nam Saejong Yoo Hwi-Yool Kim Young-Rok Kim Yun Jung Heo
author_sort	Eunryel Nam
title	Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
title_short	Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
title_full	Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
title_fullStr	Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
title_full_unstemmed	Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
title_sort	transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cd52fff2541242c5bafefbf0039f3cf5
work_keys_str_mv	AT eunryelnam transdermalwaterinoilnanocarriersofnitricoxidefortriggeringpenileerection AT saejongyoo transdermalwaterinoilnanocarriersofnitricoxidefortriggeringpenileerection AT hwiyoolkim transdermalwaterinoilnanocarriersofnitricoxidefortriggeringpenileerection AT youngrokkim transdermalwaterinoilnanocarriersofnitricoxidefortriggeringpenileerection AT yunjungheo transdermalwaterinoilnanocarriersofnitricoxidefortriggeringpenileerection
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Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection

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