ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.

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Autores principales:	Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P. Heinzen, Daniel R. O’Brien, Ann L. Oberg, S. John Weroha, Scott H. Kaufmann, Larry M. Karnitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd553ee268364657964406f6c999755e
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spelling	oai:doaj.org-article:cd553ee268364657964406f6c999755e2021-12-02T15:36:06ZZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer10.1038/s41467-019-12610-x2041-1723https://doaj.org/article/cd553ee268364657964406f6c999755e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12610-xhttps://doaj.org/toc/2041-1723High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.Arun KanakkantharaCatherine J. HuntoonXiaonan HouMinzhi ZhangEthan P. HeinzenDaniel R. O’BrienAnn L. ObergS. John WerohaScott H. KaufmannLarry M. KarnitzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
description	High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.
format	article
author	Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz
author_facet	Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz
author_sort	Arun Kanakkanthara
title	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_short	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_full	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_fullStr	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_full_unstemmed	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_sort	zc3h18 specifically binds and activates the brca1 promoter to facilitate homologous recombination in ovarian cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cd553ee268364657964406f6c999755e
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ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

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