Application of nanotechnology in the diagnosis and treatment of bladder cancer

Abstract Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need...

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Autores principales:	Yadong Xu, Cheng Luo, Jieqiong Wang, Lingwu Chen, Junxing Chen, Tianfeng Chen, Qinsong Zeng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Nanotechnology Bladder cancer Nanoparticles Diagnosis Therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/cd56a5516f0f450c8f6bffa3c2e7c3d8
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spelling	oai:doaj.org-article:cd56a5516f0f450c8f6bffa3c2e7c3d82021-11-28T12:26:42ZApplication of nanotechnology in the diagnosis and treatment of bladder cancer10.1186/s12951-021-01104-y1477-3155https://doaj.org/article/cd56a5516f0f450c8f6bffa3c2e7c3d82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01104-yhttps://doaj.org/toc/1477-3155Abstract Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management. Graphical AbstractYadong XuCheng LuoJieqiong WangLingwu ChenJunxing ChenTianfeng ChenQinsong ZengBMCarticleNanotechnologyBladder cancerNanoparticlesDiagnosisTherapyBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanotechnology Bladder cancer Nanoparticles Diagnosis Therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Nanotechnology Bladder cancer Nanoparticles Diagnosis Therapy Biotechnology TP248.13-248.65 Medical technology R855-855.5 Yadong Xu Cheng Luo Jieqiong Wang Lingwu Chen Junxing Chen Tianfeng Chen Qinsong Zeng Application of nanotechnology in the diagnosis and treatment of bladder cancer
description	Abstract Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management. Graphical Abstract
format	article
author	Yadong Xu Cheng Luo Jieqiong Wang Lingwu Chen Junxing Chen Tianfeng Chen Qinsong Zeng
author_facet	Yadong Xu Cheng Luo Jieqiong Wang Lingwu Chen Junxing Chen Tianfeng Chen Qinsong Zeng
author_sort	Yadong Xu
title	Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_short	Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_full	Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_fullStr	Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_full_unstemmed	Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_sort	application of nanotechnology in the diagnosis and treatment of bladder cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cd56a5516f0f450c8f6bffa3c2e7c3d8
work_keys_str_mv	AT yadongxu applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT chengluo applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT jieqiongwang applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT lingwuchen applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT junxingchen applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT tianfengchen applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer AT qinsongzeng applicationofnanotechnologyinthediagnosisandtreatmentofbladdercancer
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Application of nanotechnology in the diagnosis and treatment of bladder cancer

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