Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics
Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with poten...
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oai:doaj.org-article:cd56f9468fb04771a87c0b833653f5232021-11-11T17:25:46ZCationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics10.3390/ijms2221120281422-00671661-6596https://doaj.org/article/cd56f9468fb04771a87c0b833653f5232021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12028https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with potential biological activity. The coordination behavior of all ligands with Cu(II) and Ni(II) ions has been examined. Various analytical methods such as potentiometric titration, UV-Vis and CD spectroscopies, and mass spectrometry were used. All compounds are convenient chelators for metal ion-binding. Two of the ligands tested have histidine residues. Surprisingly, imidazole nitrogen is not involved in the coordination of the metal ion. The <i>N</i>-terminal amino group, Dab side chains, and amide nitrogen atoms of the peptide bonds coordinated Cu(II) and Ni(II) in all the complexes formed. The cytotoxicity of three pseudopeptides and their complexes was evaluated. Moreover, their other model allowed for assessing the attenuation of LPS-induced cytotoxicity and anti-inflammatory activities were also evaluated, the results of which revealed to be very promising.Aleksandra KotyniaBenita WiatrakWojciech KamyszDamian NeubauerPaulina JawieńAleksandra MarciniakMDPI AGarticlecationic peptidesCu(II) complexesNi(II) complexesanti-inflammatorypotentiometric titrationspectroscopic methodsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12028, p 12028 (2021) |
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cationic peptides Cu(II) complexes Ni(II) complexes anti-inflammatory potentiometric titration spectroscopic methods Biology (General) QH301-705.5 Chemistry QD1-999 |
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cationic peptides Cu(II) complexes Ni(II) complexes anti-inflammatory potentiometric titration spectroscopic methods Biology (General) QH301-705.5 Chemistry QD1-999 Aleksandra Kotynia Benita Wiatrak Wojciech Kamysz Damian Neubauer Paulina Jawień Aleksandra Marciniak Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
description |
Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with potential biological activity. The coordination behavior of all ligands with Cu(II) and Ni(II) ions has been examined. Various analytical methods such as potentiometric titration, UV-Vis and CD spectroscopies, and mass spectrometry were used. All compounds are convenient chelators for metal ion-binding. Two of the ligands tested have histidine residues. Surprisingly, imidazole nitrogen is not involved in the coordination of the metal ion. The <i>N</i>-terminal amino group, Dab side chains, and amide nitrogen atoms of the peptide bonds coordinated Cu(II) and Ni(II) in all the complexes formed. The cytotoxicity of three pseudopeptides and their complexes was evaluated. Moreover, their other model allowed for assessing the attenuation of LPS-induced cytotoxicity and anti-inflammatory activities were also evaluated, the results of which revealed to be very promising. |
format |
article |
author |
Aleksandra Kotynia Benita Wiatrak Wojciech Kamysz Damian Neubauer Paulina Jawień Aleksandra Marciniak |
author_facet |
Aleksandra Kotynia Benita Wiatrak Wojciech Kamysz Damian Neubauer Paulina Jawień Aleksandra Marciniak |
author_sort |
Aleksandra Kotynia |
title |
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
title_short |
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
title_full |
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
title_fullStr |
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
title_full_unstemmed |
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics |
title_sort |
cationic peptides and their cu(ii) and ni(ii) complexes: coordination and biological characteristics |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/cd56f9468fb04771a87c0b833653f523 |
work_keys_str_mv |
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