UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS

Objective: To validate if Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte ratio (PLR) or CALL score (a novel scoring model) predict worse prognosis such as need for Intensive Care Unit (ICU) Admission and Mortality in COVID 19 patients. Study Design: Prospective observational cohort...

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Autores principales:	Asma Asghar, Usman Saqib, Saba Aijaz, Karamat Hussain Shah Bukhari, Arshad Hayat
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	call score covid 19 neutrophil to lymphocyte ratio platelet to lymphocyte ratio prognostic markers Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd5a8e73dca943679729e7e820dae38a
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spelling	oai:doaj.org-article:cd5a8e73dca943679729e7e820dae38a2021-12-02T14:55:05ZUTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS0030-96482411-8842https://doaj.org/article/cd5a8e73dca943679729e7e820dae38a2020-09-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5289https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To validate if Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte ratio (PLR) or CALL score (a novel scoring model) predict worse prognosis such as need for Intensive Care Unit (ICU) Admission and Mortality in COVID 19 patients. Study Design: Prospective observational cohort study. Place and Duration of Study: Combined Military Hospital Lahore, from Mar 2020 to May 2020. Methodology: Consecutive symptomatic patients with confirmed COVID-19 infection by RT-PCR were included. Patients’ age, gender, comorbids and labs data including complete blood counts and serum LDH was recorded. neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and CALL Score were calculated. Main outcomes were need for Intensive Care Unit Admission/ventilator support and mortality. Results: A total of 125 patients were admitted with the diagnosis of COVID-19 infection. There were 35 (28%) Intensive Care Unit admissions, 17 (13.6%) required mechanical ventilation and 17 (13.6%) patients were deceased. Regression Analysis was done. For Intensive Care Unit Admission/ventilator support significant predictors were neutrophil-to-lymphocyte ratio (p=0.03), age greater than 50 (p=0.02), moderate CALL score (p=0.02) and high CALL Score (p=0.004). For hospital deaths, significant predictors included neutrophil-tolymphocyte ratio (p=0.001) and age more than 50 years (p=0.01), CALL Score was not significant (p=0.3 & 0.9). Platelet-to-lymphocyte ratio (p=0.9 and 0.8) and Diabetes (p=0.1 & 0.6) were not significant. Conclusion: Neutrophil-to-lymphocyte ratio and age more than 50 years are significant predictors for need for Intensive Care Unit Admission or Ventilatory support and in-hospital mortality. High CALL Score is a significant predictor of Intensive Care Unit Admission or ventilator support but not for in hospital mortality.Asma AsgharUsman SaqibSaba AijazKaramat Hussain Shah BukhariArshad HayatArmy Medical College Rawalpindiarticlecall scorecovid 19neutrophil to lymphocyte ratioplatelet to lymphocyte ratioprognostic markersMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 2, Pp 590-596 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	call score covid 19 neutrophil to lymphocyte ratio platelet to lymphocyte ratio prognostic markers Medicine R Medicine (General) R5-920
spellingShingle	call score covid 19 neutrophil to lymphocyte ratio platelet to lymphocyte ratio prognostic markers Medicine R Medicine (General) R5-920 Asma Asghar Usman Saqib Saba Aijaz Karamat Hussain Shah Bukhari Arshad Hayat UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
description	Objective: To validate if Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte ratio (PLR) or CALL score (a novel scoring model) predict worse prognosis such as need for Intensive Care Unit (ICU) Admission and Mortality in COVID 19 patients. Study Design: Prospective observational cohort study. Place and Duration of Study: Combined Military Hospital Lahore, from Mar 2020 to May 2020. Methodology: Consecutive symptomatic patients with confirmed COVID-19 infection by RT-PCR were included. Patients’ age, gender, comorbids and labs data including complete blood counts and serum LDH was recorded. neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and CALL Score were calculated. Main outcomes were need for Intensive Care Unit Admission/ventilator support and mortality. Results: A total of 125 patients were admitted with the diagnosis of COVID-19 infection. There were 35 (28%) Intensive Care Unit admissions, 17 (13.6%) required mechanical ventilation and 17 (13.6%) patients were deceased. Regression Analysis was done. For Intensive Care Unit Admission/ventilator support significant predictors were neutrophil-to-lymphocyte ratio (p=0.03), age greater than 50 (p=0.02), moderate CALL score (p=0.02) and high CALL Score (p=0.004). For hospital deaths, significant predictors included neutrophil-tolymphocyte ratio (p=0.001) and age more than 50 years (p=0.01), CALL Score was not significant (p=0.3 & 0.9). Platelet-to-lymphocyte ratio (p=0.9 and 0.8) and Diabetes (p=0.1 & 0.6) were not significant. Conclusion: Neutrophil-to-lymphocyte ratio and age more than 50 years are significant predictors for need for Intensive Care Unit Admission or Ventilatory support and in-hospital mortality. High CALL Score is a significant predictor of Intensive Care Unit Admission or ventilator support but not for in hospital mortality.
format	article
author	Asma Asghar Usman Saqib Saba Aijaz Karamat Hussain Shah Bukhari Arshad Hayat
author_facet	Asma Asghar Usman Saqib Saba Aijaz Karamat Hussain Shah Bukhari Arshad Hayat
author_sort	Asma Asghar
title	UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
title_short	UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
title_full	UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
title_fullStr	UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
title_full_unstemmed	UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS
title_sort	utility of neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio and call score for prognosis assessment in covid-19 patients
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/cd5a8e73dca943679729e7e820dae38a
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UTILITY OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELETS-TO-LYMPHOCYTE RATIO AND CALL SCORE FOR PROGNOSIS ASSESSMENT IN COVID-19 PATIENTS

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