Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles

Min Xu,1,2,* Chong Yao,3,* Wei Zhang,1 Shen Gao,1 Hao Zou,1 Jing Gao1,4 1School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China; 2Department of Pharmacy, Changzheng Hospital, Shanghai, 200003, People’s Republic of China; 3Clinical Pha...

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Autores principales:	Xu M, Yao C, Zhang W, Gao S, Zou H, Gao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	poly(2-oxazoline)s micelle docetaxel high loading anti-cancer activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd5bc51a94c345a6ad05ec1c9134881a
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spelling	oai:doaj.org-article:cd5bc51a94c345a6ad05ec1c9134881a2021-12-02T17:00:14ZAnti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles1178-2013https://doaj.org/article/cd5bc51a94c345a6ad05ec1c9134881a2021-04-01T00:00:00Zhttps://www.dovepress.com/anti-cancer-activity-based-on-the-high-docetaxel-loaded-poly2-oxazolin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Min Xu,1,2,* Chong Yao,3,* Wei Zhang,1 Shen Gao,1 Hao Zou,1 Jing Gao1,4 1School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China; 2Department of Pharmacy, Changzheng Hospital, Shanghai, 200003, People’s Republic of China; 3Clinical Pharmacy Center, Department of Pharmacy, Chinese PLA General Hospital, Beijing, 100850, People’s Republic of China; 4State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Gao; Hao ZouSchool of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Yangpu District, Shanghai, People’s Republic of ChinaTel +86-10-6687-4665Email gjsmmu@126.com; haozou@smmu.edu.cnPurpose: Nanocarriers, with a high drug loading content and good safety, to achieve desirable therapeutic effect are always the goals for industry and research.Methods and Results: In the present study, we developed a docetaxel loaded poly-2-oxazoline polymer micellar system which employed poly-2-butyl-2 oxazoline and poly-2-methyl-2 oxazoline as the hydrophobic chain and hydrophilic chain, respectively. This micellar system achieves a high load up to 25% against the docetaxel, and further demonstrates an IC50 as low as 40% of the commercialized docetaxel injection in vitro and a double maximum tolerated dose in MCF-7 cells in vivo.Conclusion: The high drug loading content, superior safety, and considerable anti-cancer activity make this newly developed docetaxel loaded poly(2-oxazoline) micelle go further in future clinical research.Keywords: poly(2-oxazoline)s, micelle, docetaxel, high loading, anti-cancer activityXu MYao CZhang WGao SZou HGao JDove Medical Pressarticlepoly(2-oxazoline)smicelledocetaxelhigh loadinganti-cancer activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2735-2749 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	poly(2-oxazoline)s micelle docetaxel high loading anti-cancer activity Medicine (General) R5-920
spellingShingle	poly(2-oxazoline)s micelle docetaxel high loading anti-cancer activity Medicine (General) R5-920 Xu M Yao C Zhang W Gao S Zou H Gao J Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
description	Min Xu,1,2,* Chong Yao,3,* Wei Zhang,1 Shen Gao,1 Hao Zou,1 Jing Gao1,4 1School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China; 2Department of Pharmacy, Changzheng Hospital, Shanghai, 200003, People’s Republic of China; 3Clinical Pharmacy Center, Department of Pharmacy, Chinese PLA General Hospital, Beijing, 100850, People’s Republic of China; 4State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Gao; Hao ZouSchool of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Yangpu District, Shanghai, People’s Republic of ChinaTel +86-10-6687-4665Email gjsmmu@126.com; haozou@smmu.edu.cnPurpose: Nanocarriers, with a high drug loading content and good safety, to achieve desirable therapeutic effect are always the goals for industry and research.Methods and Results: In the present study, we developed a docetaxel loaded poly-2-oxazoline polymer micellar system which employed poly-2-butyl-2 oxazoline and poly-2-methyl-2 oxazoline as the hydrophobic chain and hydrophilic chain, respectively. This micellar system achieves a high load up to 25% against the docetaxel, and further demonstrates an IC50 as low as 40% of the commercialized docetaxel injection in vitro and a double maximum tolerated dose in MCF-7 cells in vivo.Conclusion: The high drug loading content, superior safety, and considerable anti-cancer activity make this newly developed docetaxel loaded poly(2-oxazoline) micelle go further in future clinical research.Keywords: poly(2-oxazoline)s, micelle, docetaxel, high loading, anti-cancer activity
format	article
author	Xu M Yao C Zhang W Gao S Zou H Gao J
author_facet	Xu M Yao C Zhang W Gao S Zou H Gao J
author_sort	Xu M
title	Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_short	Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_full	Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_fullStr	Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_full_unstemmed	Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles
title_sort	anti-cancer activity based on the high docetaxel loaded poly(2-oxazoline)s micelles
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/cd5bc51a94c345a6ad05ec1c9134881a
work_keys_str_mv	AT xum anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles AT yaoc anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles AT zhangw anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles AT gaos anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles AT zouh anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles AT gaoj anticanceractivitybasedonthehighdocetaxelloadedpoly2oxazolinesmicelles
_version_	1718382295657742336

Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles

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