Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Abstract Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in the brain voltage-gated sodium channel gene SCN1A. Heterozygous Scn1a knockout (Scn1a +/−) mice recapitulate the severe epilepsy phenotype of Dravet syndrome and...

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Autores principales: Lyndsey L. Anderson, Nicole A. Hawkins, Christopher H. Thompson, Jennifer A. Kearney, Alfred L. George
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cd5cb4d1c7b74bacabd1a415c917f263
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