Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study.
<h4>Background</h4>Women who smoke have higher risk of lung function impairment, COPD and lung cancer than smoking men. An influence of sex hormones has been demonstrated, but the mechanisms are unclear and the associations often subject to confounding. This was a study of wheeze in rela...
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oai:doaj.org-article:cd5dea81e42b40c5bd5580fd770f84e42021-11-18T08:00:16ZHigher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study.1932-620310.1371/journal.pone.0054137https://doaj.org/article/cd5dea81e42b40c5bd5580fd770f84e42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23357876/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Women who smoke have higher risk of lung function impairment, COPD and lung cancer than smoking men. An influence of sex hormones has been demonstrated, but the mechanisms are unclear and the associations often subject to confounding. This was a study of wheeze in relation to smoking and sex with adjustment for important confounders.<h4>Methods</h4>In 2008 the Global Allergy and Asthma European Network (GA(2)LEN) questionnaire was mailed to 45.000 Swedes (age 16-75 years), and 26.851 (60%) participated. "Any wheeze": any wheeze during the last 12 months. "Asthmatic wheeze": wheeze with breathlessness apart from colds.<h4>Results</h4>Any wheeze and asthmatic wheeze was reported by 17.3% and 7.1% of women, vs. 15.8% and 6.1% of men (both p<0.001). Although smoking prevalence was similar in both sexes, men had greater cumulative exposure, 16.2 pack-years vs. 12.8 in women (p<0.001). Most other exposures and characteristics associated with wheeze were significantly overrepresented in men. Adjusted for these potential confounders and pack-years, current smoking was a stronger risk factor for any wheeze in women aged <53 years, adjusted odds ratio (aOR) 1.85 (1.56-2.19) vs. 1.60 (1.30-1.96) in men. Cumulative smoke exposure and current smoking each interacted significantly with female sex, aOR 1.02 per pack-year (p<0.01) and aOR 1.28 (p = 0.04) respectively. Female compared to male current smokers also had greater risk of asthmatic wheeze, aOR 1.53 vs. 1.03, interaction aOR 1.52 (p = 0.02). These interactions were not seen in age ≥ 53 years.<h4>Discussion</h4>In addition to the increased risk of COPD and lung cancer female, compared to male, smokers are at greater risk of significant wheezing symptoms in younger age. This became clearer after adjustment for important confounders including cumulative smoke exposure. Estrogen has previously been shown to increase the bioactivation of several compounds in tobacco smoke, which may enhance smoke-induced airway inflammation in fertile women.Anders BjergLinda EkerljungJonas ErikssonInga Sif ÓlafsdóttirRoelinde MiddelveldKarl A FranklinBertil ForsbergKjell LarssonJan LötvallKjell TorénSven-Erik DahlénBo LundbäckChrister JansonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54137 (2013) |
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Medicine R Science Q Anders Bjerg Linda Ekerljung Jonas Eriksson Inga Sif Ólafsdóttir Roelinde Middelveld Karl A Franklin Bertil Forsberg Kjell Larsson Jan Lötvall Kjell Torén Sven-Erik Dahlén Bo Lundbäck Christer Janson Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| description |
<h4>Background</h4>Women who smoke have higher risk of lung function impairment, COPD and lung cancer than smoking men. An influence of sex hormones has been demonstrated, but the mechanisms are unclear and the associations often subject to confounding. This was a study of wheeze in relation to smoking and sex with adjustment for important confounders.<h4>Methods</h4>In 2008 the Global Allergy and Asthma European Network (GA(2)LEN) questionnaire was mailed to 45.000 Swedes (age 16-75 years), and 26.851 (60%) participated. "Any wheeze": any wheeze during the last 12 months. "Asthmatic wheeze": wheeze with breathlessness apart from colds.<h4>Results</h4>Any wheeze and asthmatic wheeze was reported by 17.3% and 7.1% of women, vs. 15.8% and 6.1% of men (both p<0.001). Although smoking prevalence was similar in both sexes, men had greater cumulative exposure, 16.2 pack-years vs. 12.8 in women (p<0.001). Most other exposures and characteristics associated with wheeze were significantly overrepresented in men. Adjusted for these potential confounders and pack-years, current smoking was a stronger risk factor for any wheeze in women aged <53 years, adjusted odds ratio (aOR) 1.85 (1.56-2.19) vs. 1.60 (1.30-1.96) in men. Cumulative smoke exposure and current smoking each interacted significantly with female sex, aOR 1.02 per pack-year (p<0.01) and aOR 1.28 (p = 0.04) respectively. Female compared to male current smokers also had greater risk of asthmatic wheeze, aOR 1.53 vs. 1.03, interaction aOR 1.52 (p = 0.02). These interactions were not seen in age ≥ 53 years.<h4>Discussion</h4>In addition to the increased risk of COPD and lung cancer female, compared to male, smokers are at greater risk of significant wheezing symptoms in younger age. This became clearer after adjustment for important confounders including cumulative smoke exposure. Estrogen has previously been shown to increase the bioactivation of several compounds in tobacco smoke, which may enhance smoke-induced airway inflammation in fertile women. |
| format |
article |
| author |
Anders Bjerg Linda Ekerljung Jonas Eriksson Inga Sif Ólafsdóttir Roelinde Middelveld Karl A Franklin Bertil Forsberg Kjell Larsson Jan Lötvall Kjell Torén Sven-Erik Dahlén Bo Lundbäck Christer Janson |
| author_facet |
Anders Bjerg Linda Ekerljung Jonas Eriksson Inga Sif Ólafsdóttir Roelinde Middelveld Karl A Franklin Bertil Forsberg Kjell Larsson Jan Lötvall Kjell Torén Sven-Erik Dahlén Bo Lundbäck Christer Janson |
| author_sort |
Anders Bjerg |
| title |
Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| title_short |
Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| title_full |
Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| title_fullStr |
Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| title_full_unstemmed |
Higher risk of wheeze in female than male smokers. Results from the Swedish GA 2 LEN study. |
| title_sort |
higher risk of wheeze in female than male smokers. results from the swedish ga 2 len study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/cd5dea81e42b40c5bd5580fd770f84e4 |
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