Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucida...

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Autores principales: Haihong Zhang, Yanli Wang, Jinghui Feng, Shuya Wang, Yan Wang, Weisi Kong, Zhiyi Zhang
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:cd5df5cf3da14a64a2feba164424905a2021-11-04T06:12:07ZIntegrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus1664-802110.3389/fgene.2021.782005https://doaj.org/article/cd5df5cf3da14a64a2feba164424905a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.782005/fullhttps://doaj.org/toc/1664-8021Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucidated. To clarify the potential pathogenic mechanism of SLE, we performed an integrated analysis of two RNA-seq datasets of SLE. Differential expression analysis revealed that there were 4,713 and 2,473 differentially expressed genes, respectively, most of which were up-regulated. After integrating differentially expressed genes, we identified 790 common differentially expressed genes (DEGs). Gene functional enrichment analysis was performed and found that common differentially expressed genes were significantly enriched in some important immune-related biological processes and pathways. Our analysis provides new insights into a better understanding of the pathogenic mechanisms and potential candidate markers for systemic lupus erythematosus.Haihong ZhangYanli WangJinghui FengShuya WangYan WangWeisi KongZhiyi ZhangFrontiers Media S.A.articlesystemic lupus erythematosusdifferential expression analysisgene functional enrichment analysisRNA-seqprotein-protein interactionGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic systemic lupus erythematosus
differential expression analysis
gene functional enrichment analysis
RNA-seq
protein-protein interaction
Genetics
QH426-470
spellingShingle systemic lupus erythematosus
differential expression analysis
gene functional enrichment analysis
RNA-seq
protein-protein interaction
Genetics
QH426-470
Haihong Zhang
Yanli Wang
Jinghui Feng
Shuya Wang
Yan Wang
Weisi Kong
Zhiyi Zhang
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
description Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucidated. To clarify the potential pathogenic mechanism of SLE, we performed an integrated analysis of two RNA-seq datasets of SLE. Differential expression analysis revealed that there were 4,713 and 2,473 differentially expressed genes, respectively, most of which were up-regulated. After integrating differentially expressed genes, we identified 790 common differentially expressed genes (DEGs). Gene functional enrichment analysis was performed and found that common differentially expressed genes were significantly enriched in some important immune-related biological processes and pathways. Our analysis provides new insights into a better understanding of the pathogenic mechanisms and potential candidate markers for systemic lupus erythematosus.
format article
author Haihong Zhang
Yanli Wang
Jinghui Feng
Shuya Wang
Yan Wang
Weisi Kong
Zhiyi Zhang
author_facet Haihong Zhang
Yanli Wang
Jinghui Feng
Shuya Wang
Yan Wang
Weisi Kong
Zhiyi Zhang
author_sort Haihong Zhang
title Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
title_short Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
title_full Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
title_fullStr Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
title_full_unstemmed Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
title_sort integrative analysis for elucidating transcriptomics landscapes of systemic lupus erythematosus
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/cd5df5cf3da14a64a2feba164424905a
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AT yanwang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus
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