Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucida...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:cd5df5cf3da14a64a2feba164424905a2021-11-04T06:12:07ZIntegrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus1664-802110.3389/fgene.2021.782005https://doaj.org/article/cd5df5cf3da14a64a2feba164424905a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.782005/fullhttps://doaj.org/toc/1664-8021Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucidated. To clarify the potential pathogenic mechanism of SLE, we performed an integrated analysis of two RNA-seq datasets of SLE. Differential expression analysis revealed that there were 4,713 and 2,473 differentially expressed genes, respectively, most of which were up-regulated. After integrating differentially expressed genes, we identified 790 common differentially expressed genes (DEGs). Gene functional enrichment analysis was performed and found that common differentially expressed genes were significantly enriched in some important immune-related biological processes and pathways. Our analysis provides new insights into a better understanding of the pathogenic mechanisms and potential candidate markers for systemic lupus erythematosus.Haihong ZhangYanli WangJinghui FengShuya WangYan WangWeisi KongZhiyi ZhangFrontiers Media S.A.articlesystemic lupus erythematosusdifferential expression analysisgene functional enrichment analysisRNA-seqprotein-protein interactionGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
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systemic lupus erythematosus differential expression analysis gene functional enrichment analysis RNA-seq protein-protein interaction Genetics QH426-470 |
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systemic lupus erythematosus differential expression analysis gene functional enrichment analysis RNA-seq protein-protein interaction Genetics QH426-470 Haihong Zhang Yanli Wang Jinghui Feng Shuya Wang Yan Wang Weisi Kong Zhiyi Zhang Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
description |
Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucidated. To clarify the potential pathogenic mechanism of SLE, we performed an integrated analysis of two RNA-seq datasets of SLE. Differential expression analysis revealed that there were 4,713 and 2,473 differentially expressed genes, respectively, most of which were up-regulated. After integrating differentially expressed genes, we identified 790 common differentially expressed genes (DEGs). Gene functional enrichment analysis was performed and found that common differentially expressed genes were significantly enriched in some important immune-related biological processes and pathways. Our analysis provides new insights into a better understanding of the pathogenic mechanisms and potential candidate markers for systemic lupus erythematosus. |
format |
article |
author |
Haihong Zhang Yanli Wang Jinghui Feng Shuya Wang Yan Wang Weisi Kong Zhiyi Zhang |
author_facet |
Haihong Zhang Yanli Wang Jinghui Feng Shuya Wang Yan Wang Weisi Kong Zhiyi Zhang |
author_sort |
Haihong Zhang |
title |
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
title_short |
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
title_full |
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
title_fullStr |
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
title_full_unstemmed |
Integrative Analysis for Elucidating Transcriptomics Landscapes of Systemic Lupus Erythematosus |
title_sort |
integrative analysis for elucidating transcriptomics landscapes of systemic lupus erythematosus |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/cd5df5cf3da14a64a2feba164424905a |
work_keys_str_mv |
AT haihongzhang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT yanliwang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT jinghuifeng integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT shuyawang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT yanwang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT weisikong integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus AT zhiyizhang integrativeanalysisforelucidatingtranscriptomicslandscapesofsystemiclupuserythematosus |
_version_ |
1718445117006675968 |