Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.

Patterns of modern human population structure are helpful in understanding the history of human migration and admixture. We conducted a study on genetic structure of the Malay population in Malaysia, using 54,794 genome-wide single nucleotide polymorphism genotype data generated in four Malay sub-et...

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Autores principales:	Wan Isa Hatin, Ab Rajab Nur-Shafawati, Mohd-Khairi Zahri, Shuhua Xu, Li Jin, Soon-Guan Tan, Mohammed Rizman-Idid, Bin Alwi Zilfalil, HUGO Pan-Asian SNP Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd64895f47d24898a23bf993fa6c2a9f
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spelling	oai:doaj.org-article:cd64895f47d24898a23bf993fa6c2a9f2021-11-18T06:56:12ZPopulation genetic structure of peninsular Malaysia Malay sub-ethnic groups.1932-620310.1371/journal.pone.0018312https://doaj.org/article/cd64895f47d24898a23bf993fa6c2a9f2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483678/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Patterns of modern human population structure are helpful in understanding the history of human migration and admixture. We conducted a study on genetic structure of the Malay population in Malaysia, using 54,794 genome-wide single nucleotide polymorphism genotype data generated in four Malay sub-ethnic groups in peninsular Malaysia (Melayu Kelantan, Melayu Minang, Melayu Jawa and Melayu Bugis). To the best of our knowledge this is the first study conducted on these four Malay sub-ethnic groups and the analysis of genotype data of these four groups were compiled together with 11 other populations' genotype data from Indonesia, China, India, Africa and indigenous populations in Peninsular Malaysia obtained from the Pan-Asian SNP database. The phylogeny of populations showed that all of the four Malay sub-ethnic groups are separated into at least three different clusters. The Melayu Jawa, Melayu Bugis and Melayu Minang have a very close genetic relationship with Indonesian populations indicating a common ancestral history, while the Melayu Kelantan formed a distinct group on the tree indicating that they are genetically different from the other Malay sub-ethnic groups. We have detected genetic structuring among the Malay populations and this could possibly be accounted for by their different historical origins. Our results provide information of the genetic differentiation between these populations and a valuable insight into the origins of the Malay sub-ethnic groups in Peninsular Malaysia.Wan Isa HatinAb Rajab Nur-ShafawatiMohd-Khairi ZahriShuhua XuLi JinSoon-Guan TanMohammed Rizman-IdidBin Alwi ZilfalilHUGO Pan-Asian SNP ConsortiumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18312 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan Isa Hatin Ab Rajab Nur-Shafawati Mohd-Khairi Zahri Shuhua Xu Li Jin Soon-Guan Tan Mohammed Rizman-Idid Bin Alwi Zilfalil HUGO Pan-Asian SNP Consortium Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
description	Patterns of modern human population structure are helpful in understanding the history of human migration and admixture. We conducted a study on genetic structure of the Malay population in Malaysia, using 54,794 genome-wide single nucleotide polymorphism genotype data generated in four Malay sub-ethnic groups in peninsular Malaysia (Melayu Kelantan, Melayu Minang, Melayu Jawa and Melayu Bugis). To the best of our knowledge this is the first study conducted on these four Malay sub-ethnic groups and the analysis of genotype data of these four groups were compiled together with 11 other populations' genotype data from Indonesia, China, India, Africa and indigenous populations in Peninsular Malaysia obtained from the Pan-Asian SNP database. The phylogeny of populations showed that all of the four Malay sub-ethnic groups are separated into at least three different clusters. The Melayu Jawa, Melayu Bugis and Melayu Minang have a very close genetic relationship with Indonesian populations indicating a common ancestral history, while the Melayu Kelantan formed a distinct group on the tree indicating that they are genetically different from the other Malay sub-ethnic groups. We have detected genetic structuring among the Malay populations and this could possibly be accounted for by their different historical origins. Our results provide information of the genetic differentiation between these populations and a valuable insight into the origins of the Malay sub-ethnic groups in Peninsular Malaysia.
format	article
author	Wan Isa Hatin Ab Rajab Nur-Shafawati Mohd-Khairi Zahri Shuhua Xu Li Jin Soon-Guan Tan Mohammed Rizman-Idid Bin Alwi Zilfalil HUGO Pan-Asian SNP Consortium
author_facet	Wan Isa Hatin Ab Rajab Nur-Shafawati Mohd-Khairi Zahri Shuhua Xu Li Jin Soon-Guan Tan Mohammed Rizman-Idid Bin Alwi Zilfalil HUGO Pan-Asian SNP Consortium
author_sort	Wan Isa Hatin
title	Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
title_short	Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
title_full	Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
title_fullStr	Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
title_full_unstemmed	Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.
title_sort	population genetic structure of peninsular malaysia malay sub-ethnic groups.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/cd64895f47d24898a23bf993fa6c2a9f
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Population genetic structure of peninsular Malaysia Malay sub-ethnic groups.

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