Genes influencing circadian differences in blood pressure in hypertensive mice.

Essential hypertension is a common multifactorial heritable condition in which increased sympathetic outflow from the central nervous system is involved in the elevation in blood pressure (BP), as well as the exaggerated morning surge in BP that is a risk factor for myocardial infarction and stroke...

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Autores principales:	Francine Z Marques, Anna E Campain, Pamela J Davern, Yee Hwa J Yang, Geoffrey A Head, Brian J Morris
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd6521f2940048bd8203c0eba946df79
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spelling	oai:doaj.org-article:cd6521f2940048bd8203c0eba946df792021-11-18T06:55:08ZGenes influencing circadian differences in blood pressure in hypertensive mice.1932-620310.1371/journal.pone.0019203https://doaj.org/article/cd6521f2940048bd8203c0eba946df792011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541337/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Essential hypertension is a common multifactorial heritable condition in which increased sympathetic outflow from the central nervous system is involved in the elevation in blood pressure (BP), as well as the exaggerated morning surge in BP that is a risk factor for myocardial infarction and stroke in hypertensive patients. The Schlager BPH/2J mouse is a genetic model of hypertension in which increased sympathetic outflow from the hypothalamus has an important etiological role in the elevation of BP. Schlager hypertensive mice exhibit a large variation in BP between the active and inactive periods of the day, and also show a morning surge in BP. To investigate the genes responsible for the circadian variation in BP in hypertension, hypothalamic tissue was collected from BPH/2J and normotensive BPN/3J mice at the 'peak' (n = 12) and 'trough' (n = 6) of diurnal BP. Using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays, validation by quantitative real-time PCR and a statistical method that adjusted for clock genes, we identified 212 hypothalamic genes whose expression differed between 'peak' and 'trough' BP in the hypertensive strain. These included genes with known roles in BP regulation, such as vasopressin, oxytocin and thyrotropin releasing hormone, as well as genes not recognized previously as regulators of BP, including chemokine (C-C motif) ligand 19, hypocretin and zinc finger and BTB domain containing 16. Gene ontology analysis showed an enrichment of terms for inflammatory response, mitochondrial proton-transporting ATP synthase complex, structural constituent of ribosome, amongst others. In conclusion, we have identified genes whose expression differs between the peak and trough of 24-hour circadian BP in BPH/2J mice, pointing to mechanisms responsible for diurnal variation in BP. The findings may assist in the elucidation of the mechanism for the morning surge in BP in essential hypertension.Francine Z MarquesAnna E CampainPamela J DavernYee Hwa J YangGeoffrey A HeadBrian J MorrisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19203 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francine Z Marques Anna E Campain Pamela J Davern Yee Hwa J Yang Geoffrey A Head Brian J Morris Genes influencing circadian differences in blood pressure in hypertensive mice.
description	Essential hypertension is a common multifactorial heritable condition in which increased sympathetic outflow from the central nervous system is involved in the elevation in blood pressure (BP), as well as the exaggerated morning surge in BP that is a risk factor for myocardial infarction and stroke in hypertensive patients. The Schlager BPH/2J mouse is a genetic model of hypertension in which increased sympathetic outflow from the hypothalamus has an important etiological role in the elevation of BP. Schlager hypertensive mice exhibit a large variation in BP between the active and inactive periods of the day, and also show a morning surge in BP. To investigate the genes responsible for the circadian variation in BP in hypertension, hypothalamic tissue was collected from BPH/2J and normotensive BPN/3J mice at the 'peak' (n = 12) and 'trough' (n = 6) of diurnal BP. Using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays, validation by quantitative real-time PCR and a statistical method that adjusted for clock genes, we identified 212 hypothalamic genes whose expression differed between 'peak' and 'trough' BP in the hypertensive strain. These included genes with known roles in BP regulation, such as vasopressin, oxytocin and thyrotropin releasing hormone, as well as genes not recognized previously as regulators of BP, including chemokine (C-C motif) ligand 19, hypocretin and zinc finger and BTB domain containing 16. Gene ontology analysis showed an enrichment of terms for inflammatory response, mitochondrial proton-transporting ATP synthase complex, structural constituent of ribosome, amongst others. In conclusion, we have identified genes whose expression differs between the peak and trough of 24-hour circadian BP in BPH/2J mice, pointing to mechanisms responsible for diurnal variation in BP. The findings may assist in the elucidation of the mechanism for the morning surge in BP in essential hypertension.
format	article
author	Francine Z Marques Anna E Campain Pamela J Davern Yee Hwa J Yang Geoffrey A Head Brian J Morris
author_facet	Francine Z Marques Anna E Campain Pamela J Davern Yee Hwa J Yang Geoffrey A Head Brian J Morris
author_sort	Francine Z Marques
title	Genes influencing circadian differences in blood pressure in hypertensive mice.
title_short	Genes influencing circadian differences in blood pressure in hypertensive mice.
title_full	Genes influencing circadian differences in blood pressure in hypertensive mice.
title_fullStr	Genes influencing circadian differences in blood pressure in hypertensive mice.
title_full_unstemmed	Genes influencing circadian differences in blood pressure in hypertensive mice.
title_sort	genes influencing circadian differences in blood pressure in hypertensive mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/cd6521f2940048bd8203c0eba946df79
work_keys_str_mv	AT francinezmarques genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice AT annaecampain genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice AT pamelajdavern genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice AT yeehwajyang genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice AT geoffreyahead genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice AT brianjmorris genesinfluencingcircadiandifferencesinbloodpressureinhypertensivemice
_version_	1718424256880050176

Genes influencing circadian differences in blood pressure in hypertensive mice.

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