Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.
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Nature Portfolio
2020
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oai:doaj.org-article:cd666af7ab5b48228df77dcce964a1fd2021-12-02T14:16:24ZEpigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR10.1038/s41467-020-19615-x2041-1723https://doaj.org/article/cd666af7ab5b48228df77dcce964a1fd2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19615-xhttps://doaj.org/toc/2041-1723PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.Alicia K. SmithAndrew RatanatharathornAdam X. MaihoferRobert K. NaviauxAllison E. AielloAnanda B. AmstadterAllison E. Ashley-KochDewleen G. BakerJean C. BeckhamMarco P. BoksEvelyn BrometMichelle DennisSandro GaleaMelanie E. GarrettElbert GeuzeGuia GuffantiMichael A. HauserSeyma KatrinliVarun KilaruRonald C. KesslerNathan A. KimbrelKarestan C. KoenenPei-Fen KuanKefeng LiMark W. LogueAdriana LoriBenjamin J. LuftMark W. MillerJane C. NaviauxNicole R. NugentXuejun QinKerry J. ResslerVictoria B. RisbroughBart P. F. RuttenMurray B. SteinRobert J. UrsanoEric VermettenChristiaan H. VinkersLin WangNagy A. YoussefINTRuST Clinical ConsortiumVA Mid-Atlantic MIRECC WorkgroupPGC PTSD Epigenetics WorkgroupMonica UddinCaroline M. NievergeltNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Alicia K. Smith Andrew Ratanatharathorn Adam X. Maihofer Robert K. Naviaux Allison E. Aiello Ananda B. Amstadter Allison E. Ashley-Koch Dewleen G. Baker Jean C. Beckham Marco P. Boks Evelyn Bromet Michelle Dennis Sandro Galea Melanie E. Garrett Elbert Geuze Guia Guffanti Michael A. Hauser Seyma Katrinli Varun Kilaru Ronald C. Kessler Nathan A. Kimbrel Karestan C. Koenen Pei-Fen Kuan Kefeng Li Mark W. Logue Adriana Lori Benjamin J. Luft Mark W. Miller Jane C. Naviaux Nicole R. Nugent Xuejun Qin Kerry J. Ressler Victoria B. Risbrough Bart P. F. Rutten Murray B. Stein Robert J. Ursano Eric Vermetten Christiaan H. Vinkers Lin Wang Nagy A. Youssef INTRuST Clinical Consortium VA Mid-Atlantic MIRECC Workgroup PGC PTSD Epigenetics Workgroup Monica Uddin Caroline M. Nievergelt Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| description |
PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD. |
| format |
article |
| author |
Alicia K. Smith Andrew Ratanatharathorn Adam X. Maihofer Robert K. Naviaux Allison E. Aiello Ananda B. Amstadter Allison E. Ashley-Koch Dewleen G. Baker Jean C. Beckham Marco P. Boks Evelyn Bromet Michelle Dennis Sandro Galea Melanie E. Garrett Elbert Geuze Guia Guffanti Michael A. Hauser Seyma Katrinli Varun Kilaru Ronald C. Kessler Nathan A. Kimbrel Karestan C. Koenen Pei-Fen Kuan Kefeng Li Mark W. Logue Adriana Lori Benjamin J. Luft Mark W. Miller Jane C. Naviaux Nicole R. Nugent Xuejun Qin Kerry J. Ressler Victoria B. Risbrough Bart P. F. Rutten Murray B. Stein Robert J. Ursano Eric Vermetten Christiaan H. Vinkers Lin Wang Nagy A. Youssef INTRuST Clinical Consortium VA Mid-Atlantic MIRECC Workgroup PGC PTSD Epigenetics Workgroup Monica Uddin Caroline M. Nievergelt |
| author_facet |
Alicia K. Smith Andrew Ratanatharathorn Adam X. Maihofer Robert K. Naviaux Allison E. Aiello Ananda B. Amstadter Allison E. Ashley-Koch Dewleen G. Baker Jean C. Beckham Marco P. Boks Evelyn Bromet Michelle Dennis Sandro Galea Melanie E. Garrett Elbert Geuze Guia Guffanti Michael A. Hauser Seyma Katrinli Varun Kilaru Ronald C. Kessler Nathan A. Kimbrel Karestan C. Koenen Pei-Fen Kuan Kefeng Li Mark W. Logue Adriana Lori Benjamin J. Luft Mark W. Miller Jane C. Naviaux Nicole R. Nugent Xuejun Qin Kerry J. Ressler Victoria B. Risbrough Bart P. F. Rutten Murray B. Stein Robert J. Ursano Eric Vermetten Christiaan H. Vinkers Lin Wang Nagy A. Youssef INTRuST Clinical Consortium VA Mid-Atlantic MIRECC Workgroup PGC PTSD Epigenetics Workgroup Monica Uddin Caroline M. Nievergelt |
| author_sort |
Alicia K. Smith |
| title |
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| title_short |
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| title_full |
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| title_fullStr |
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| title_full_unstemmed |
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR |
| title_sort |
epigenome-wide meta-analysis of ptsd across 10 military and civilian cohorts identifies methylation changes in ahrr |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/cd666af7ab5b48228df77dcce964a1fd |
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