Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state by binding at the acidic pocket of the channel.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd6928ca293c4d9a8cd20517994d727a
record_format	dspace
spelling	oai:doaj.org-article:cd6928ca293c4d9a8cd20517994d727a2021-12-02T12:09:17ZMolecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 110.1038/s42003-021-01678-12399-3642https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01678-1https://doaj.org/toc/2399-3642Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state by binding at the acidic pocket of the channel.Yi LiuJichun MaRenee L. DesJarlaisRebecca HaganJason RechDavid LinChanglu LiuRobyn MillerJeffrey SchoellermanJinquan LuoMichael LetavicBruce GrasbergerMichael MaherNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yi Liu Jichun Ma Renee L. DesJarlais Rebecca Hagan Jason Rech David Lin Changlu Liu Robyn Miller Jeffrey Schoellerman Jinquan Luo Michael Letavic Bruce Grasberger Michael Maher Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
description	Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state by binding at the acidic pocket of the channel.
format	article
author	Yi Liu Jichun Ma Renee L. DesJarlais Rebecca Hagan Jason Rech David Lin Changlu Liu Robyn Miller Jeffrey Schoellerman Jinquan Luo Michael Letavic Bruce Grasberger Michael Maher
author_facet	Yi Liu Jichun Ma Renee L. DesJarlais Rebecca Hagan Jason Rech David Lin Changlu Liu Robyn Miller Jeffrey Schoellerman Jinquan Luo Michael Letavic Bruce Grasberger Michael Maher
author_sort	Yi Liu
title	Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
title_short	Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
title_full	Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
title_fullStr	Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
title_full_unstemmed	Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
title_sort	molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
work_keys_str_mv	AT yiliu molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT jichunma molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT reneeldesjarlais molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT rebeccahagan molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT jasonrech molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT davidlin molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT changluliu molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT robynmiller molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT jeffreyschoellerman molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT jinquanluo molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT michaelletavic molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT brucegrasberger molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1 AT michaelmaher molecularmechanismandstructuralbasisofsmallmoleculemodulationofthegatingofacidsensingionchannel1
_version_	1718394715451162624

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Ejemplares similares