Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome

Objective: To investigate the relationship between low birth weight (LBW; <2.5 kg) and preterm delivery (<37 weeks gestational age) and final renal outcome in infants with posterior urethral valves (PUVs), emphasising the risk factors for the development of chronic kidney disease (CKD). Patien...

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Autor principal:	Osama M. Sarhan
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Chronic kidney disease Low birth weight Preterm delivery Posterior urethral valves Prognosis Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/cd6bf4efcd554384bd4586e24836227d
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spelling	oai:doaj.org-article:cd6bf4efcd554384bd4586e24836227d2021-12-02T10:23:51ZPosterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome2090-598X10.1016/j.aju.2017.01.005https://doaj.org/article/cd6bf4efcd554384bd4586e24836227d2017-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X1730030Xhttps://doaj.org/toc/2090-598XObjective: To investigate the relationship between low birth weight (LBW; <2.5 kg) and preterm delivery (<37 weeks gestational age) and final renal outcome in infants with posterior urethral valves (PUVs), emphasising the risk factors for the development of chronic kidney disease (CKD). Patients and methods: A retrospective review was performed for all infants with PUVs who were treated between 1990 and 2010. In all, 52 infants were identified to have LBW and/or delivered preterm (Group 1). Infants in Group 1 were compared with a matching group (Group 2) of 60 full-term normal birth weight (NBW) infants with PUVs managed during the same period. The outcome of both groups was analysed. Results: During follow-up, CKD developed in 17 (32.5%) and 22 patients (36.5%) in Groups 1 and 2, respectively (P = 0.812). Patients with LBW or delivered preterm had significantly higher incidence of oligohydramnios (P = 0.009), increased risk of vesicostomy (P < 0.001), longer hospital stay (P < 0.001), and higher incidence of vesico-ureteric reflux (VUR, P = 0.024). In the LBW patients, initial serum creatinine, nadir serum creatinine, oligohydramnios and Neonatal Intensive Care Unit (NICU) length of stay were significant predictors of final renal outcome (P < 0.001, P = 0.002, P = 0.004 and P = 0.012, respectively). Conclusion: In our cohort of LBW and preterm delivery infants with PUVs, outcomes were similar to those of NBW full-term infants with PUVs but with an increased risk of vesicostomy, longer hospital stay, and higher incidence of VUR. LBW was associated with oligohydramnios, longer NICU admission, high initial and nadir serum creatinine, which were associated with a poor prognosis.Osama M. SarhanTaylor & Francis GrouparticleChronic kidney diseaseLow birth weightPreterm deliveryPosterior urethral valvesPrognosisDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 2, Pp 159-165 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic kidney disease Low birth weight Preterm delivery Posterior urethral valves Prognosis Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Chronic kidney disease Low birth weight Preterm delivery Posterior urethral valves Prognosis Diseases of the genitourinary system. Urology RC870-923 Osama M. Sarhan Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
description	Objective: To investigate the relationship between low birth weight (LBW; <2.5 kg) and preterm delivery (<37 weeks gestational age) and final renal outcome in infants with posterior urethral valves (PUVs), emphasising the risk factors for the development of chronic kidney disease (CKD). Patients and methods: A retrospective review was performed for all infants with PUVs who were treated between 1990 and 2010. In all, 52 infants were identified to have LBW and/or delivered preterm (Group 1). Infants in Group 1 were compared with a matching group (Group 2) of 60 full-term normal birth weight (NBW) infants with PUVs managed during the same period. The outcome of both groups was analysed. Results: During follow-up, CKD developed in 17 (32.5%) and 22 patients (36.5%) in Groups 1 and 2, respectively (P = 0.812). Patients with LBW or delivered preterm had significantly higher incidence of oligohydramnios (P = 0.009), increased risk of vesicostomy (P < 0.001), longer hospital stay (P < 0.001), and higher incidence of vesico-ureteric reflux (VUR, P = 0.024). In the LBW patients, initial serum creatinine, nadir serum creatinine, oligohydramnios and Neonatal Intensive Care Unit (NICU) length of stay were significant predictors of final renal outcome (P < 0.001, P = 0.002, P = 0.004 and P = 0.012, respectively). Conclusion: In our cohort of LBW and preterm delivery infants with PUVs, outcomes were similar to those of NBW full-term infants with PUVs but with an increased risk of vesicostomy, longer hospital stay, and higher incidence of VUR. LBW was associated with oligohydramnios, longer NICU admission, high initial and nadir serum creatinine, which were associated with a poor prognosis.
format	article
author	Osama M. Sarhan
author_facet	Osama M. Sarhan
author_sort	Osama M. Sarhan
title	Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
title_short	Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
title_full	Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
title_fullStr	Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
title_full_unstemmed	Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome
title_sort	posterior urethral valves: impact of low birth weight and preterm delivery on the final renal outcome
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/cd6bf4efcd554384bd4586e24836227d
work_keys_str_mv	AT osamamsarhan posteriorurethralvalvesimpactoflowbirthweightandpretermdeliveryonthefinalrenaloutcome
_version_	1718397319999651840

Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome

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