Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation

It remains poorly understood whether and how chaperones control protein evolution. Here the authors show how the chaperone Hsp90 shapes the sequence space of its client, poliovirus protein P1, at the polypeptide and RNA level to balance the evolutionary trade-offs between protein stability, aggregat...

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Autores principales:	Ron Geller, Sebastian Pechmann, Ashley Acevedo, Raul Andino, Judith Frydman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd6e32e4aa2746369045c30aac1fe449
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spelling	oai:doaj.org-article:cd6e32e4aa2746369045c30aac1fe4492021-12-02T17:32:00ZHsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation10.1038/s41467-018-04203-x2041-1723https://doaj.org/article/cd6e32e4aa2746369045c30aac1fe4492018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04203-xhttps://doaj.org/toc/2041-1723It remains poorly understood whether and how chaperones control protein evolution. Here the authors show how the chaperone Hsp90 shapes the sequence space of its client, poliovirus protein P1, at the polypeptide and RNA level to balance the evolutionary trade-offs between protein stability, aggregation and translation rate.Ron GellerSebastian PechmannAshley AcevedoRaul AndinoJudith FrydmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ron Geller Sebastian Pechmann Ashley Acevedo Raul Andino Judith Frydman Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
description	It remains poorly understood whether and how chaperones control protein evolution. Here the authors show how the chaperone Hsp90 shapes the sequence space of its client, poliovirus protein P1, at the polypeptide and RNA level to balance the evolutionary trade-offs between protein stability, aggregation and translation rate.
format	article
author	Ron Geller Sebastian Pechmann Ashley Acevedo Raul Andino Judith Frydman
author_facet	Ron Geller Sebastian Pechmann Ashley Acevedo Raul Andino Judith Frydman
author_sort	Ron Geller
title	Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
title_short	Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
title_full	Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
title_fullStr	Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
title_full_unstemmed	Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
title_sort	hsp90 shapes protein and rna evolution to balance trade-offs between protein stability and aggregation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cd6e32e4aa2746369045c30aac1fe449
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Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation

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