APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION

Abstract. At present time, some conflicting data concern a possible importance of apoptosis in pathogenesis of chronic hepatitis C. A significant role is ascribed to FAS/FAS-L, as a factor of hepatocyte apoptosis. CD95+ levels at the cell surfaces were studied in liver homogenates. A significant dec...

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Autores principales:	L. Ph. Skljar, E. V. Markelova, P. A. Lukynov, S. A. Sotnichenko, M. A. Shur
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic hepatitis c apoptosis cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cd74926fae6c4819a3458e493f1b4a30
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spelling	oai:doaj.org-article:cd74926fae6c4819a3458e493f1b4a302021-11-18T08:03:39ZAPOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION1563-06252313-741X10.15789/1563-0625-2008-4-5-415-422https://doaj.org/article/cd74926fae6c4819a3458e493f1b4a302014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/203https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. At present time, some conflicting data concern a possible importance of apoptosis in pathogenesis of chronic hepatitis C. A significant role is ascribed to FAS/FAS-L, as a factor of hepatocyte apoptosis. CD95+ levels at the cell surfaces were studied in liver homogenates. A significant decrease in CD95+ cells was revealed in liver samples from the patients with higher histological indexes of hepatitis activity and fibrosis. A reverse relationship between CD95+ level and local concentrations of cytokines (TNFα, IL-1, IL-10), as well as significant direct correlation with IFNγ, IL-2 values were detected, thus suggesting a failure of compensatory mechanisms of immune regulation, and predominance of anti-apoptotic viral potential over protective cellular responses. (Med. Immunol., vol. 10, N 4-5, pp 415-422).L. Ph. SkljarE. V. MarkelovaP. A. LukynovS. A. SotnichenkoM. A. ShurSPb RAACIarticlechronic hepatitis capoptosiscytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 415-422 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic hepatitis c apoptosis cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	chronic hepatitis c apoptosis cytokines Immunologic diseases. Allergy RC581-607 L. Ph. Skljar E. V. Markelova P. A. Lukynov S. A. Sotnichenko M. A. Shur APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
description	Abstract. At present time, some conflicting data concern a possible importance of apoptosis in pathogenesis of chronic hepatitis C. A significant role is ascribed to FAS/FAS-L, as a factor of hepatocyte apoptosis. CD95+ levels at the cell surfaces were studied in liver homogenates. A significant decrease in CD95+ cells was revealed in liver samples from the patients with higher histological indexes of hepatitis activity and fibrosis. A reverse relationship between CD95+ level and local concentrations of cytokines (TNFα, IL-1, IL-10), as well as significant direct correlation with IFNγ, IL-2 values were detected, thus suggesting a failure of compensatory mechanisms of immune regulation, and predominance of anti-apoptotic viral potential over protective cellular responses. (Med. Immunol., vol. 10, N 4-5, pp 415-422).
format	article
author	L. Ph. Skljar E. V. Markelova P. A. Lukynov S. A. Sotnichenko M. A. Shur
author_facet	L. Ph. Skljar E. V. Markelova P. A. Lukynov S. A. Sotnichenko M. A. Shur
author_sort	L. Ph. Skljar
title	APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
title_short	APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
title_full	APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
title_fullStr	APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
title_full_unstemmed	APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION
title_sort	apoptosis system and its relations to hepatocellular damage and some indexes of local cytokine profile chronic hcv infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cd74926fae6c4819a3458e493f1b4a30
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APOPTOSIS SYSTEM AND ITS RELATIONS TO HEPATOCELLULAR DAMAGE AND SOME INDEXES OF LOCAL CYTOKINE PROFILE CHRONIC HCV INFECTION

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