COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION

Objective: To determine median HbA1c level in patients screened for DM and compare the diagnostic accuracy of HbA1c with the currently recommended ADA cut off, using 2 hours (h) plasma glucose (2-h PG) post 75 grams oral glucose tolerance test (OGTT) as gold standard. Study Design: Cross sectiona...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aysha Habib Khan, Sheharbano Imran, Saira Furqan, Hafsa Majid, Lena Jafri, Najmul Islam
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	diabetes mellitus ethnic groups Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd776638fb404e5db5a30ff639ecabd4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd776638fb404e5db5a30ff639ecabd4
record_format	dspace
spelling	oai:doaj.org-article:cd776638fb404e5db5a30ff639ecabd42021-12-01T03:00:20ZCOMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION0030-96482411-8842https://doaj.org/article/cd776638fb404e5db5a30ff639ecabd42018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2242/1944https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine median HbA1c level in patients screened for DM and compare the diagnostic accuracy of HbA1c with the currently recommended ADA cut off, using 2 hours (h) plasma glucose (2-h PG) post 75 grams oral glucose tolerance test (OGTT) as gold standard. Study Design: Cross sectional study. Place and Duration of Study: Aga Khan University Hospital Karachi, from Jul 2014 to Nov 2015. Patients and Methods: Consecutive subjects screened by OGTT for diabetes mellitus (DM) were included. Blood sample for plasma glucose and HbA1c were analyzed on ADVIA 1800. Results: Total 146 subjects were included with median age 45 (IQR 54.2-35) years; 53% (n=77) being females. Median HbA1c of the study subjects was 6% (IQR 6.6-5.6). Positive correlation was observed between age and HbA1c [5.7% (IQR 6.2-5.3) <40 y, 6.2% (IQR 6.8-5.8) in >40 y subjects; r 0.34, p=0.000). Males had higher HbA1c than females [6.1% (IQR 6.8-5.7) years. 5.9% (IQR 6.4-5.4); r 0.17, p=0.036). HbA1c levels were significantly different amongst the different ethnic groups residing in Pakistan (p-value<0.03). HbA1c was positively correlated with FPG (r=0.59, p-value<0.001) and 2-h PG (r=0.56, p-value<0.001). Sensitivity, specificity, PPV, NPV for HbA1c at cutoff of 6.5% in diagnosing diabetes mellitus (DM) were 70%, 89%, 72% and 80% respectively. Conclusion: High median HbA1c levels is noted in our subjects. At cut off level of HbA1c ≥6.5%, 70% of subjects with DM were diagnosed using ADA criteria of 2-h PG for diabetes as gold standard. Ethnic differences were also observed in levels of HbA1c. There is a need to define cut off for our population.Aysha Habib KhanSheharbano ImranSaira FurqanHafsa MajidLena JafriNajmul IslamArmy Medical College Rawalpindiarticlediabetes mellitusethnic groupsMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1082-1087 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus ethnic groups Medicine R Medicine (General) R5-920
spellingShingle	diabetes mellitus ethnic groups Medicine R Medicine (General) R5-920 Aysha Habib Khan Sheharbano Imran Saira Furqan Hafsa Majid Lena Jafri Najmul Islam COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
description	Objective: To determine median HbA1c level in patients screened for DM and compare the diagnostic accuracy of HbA1c with the currently recommended ADA cut off, using 2 hours (h) plasma glucose (2-h PG) post 75 grams oral glucose tolerance test (OGTT) as gold standard. Study Design: Cross sectional study. Place and Duration of Study: Aga Khan University Hospital Karachi, from Jul 2014 to Nov 2015. Patients and Methods: Consecutive subjects screened by OGTT for diabetes mellitus (DM) were included. Blood sample for plasma glucose and HbA1c were analyzed on ADVIA 1800. Results: Total 146 subjects were included with median age 45 (IQR 54.2-35) years; 53% (n=77) being females. Median HbA1c of the study subjects was 6% (IQR 6.6-5.6). Positive correlation was observed between age and HbA1c [5.7% (IQR 6.2-5.3) <40 y, 6.2% (IQR 6.8-5.8) in >40 y subjects; r 0.34, p=0.000). Males had higher HbA1c than females [6.1% (IQR 6.8-5.7) years. 5.9% (IQR 6.4-5.4); r 0.17, p=0.036). HbA1c levels were significantly different amongst the different ethnic groups residing in Pakistan (p-value<0.03). HbA1c was positively correlated with FPG (r=0.59, p-value<0.001) and 2-h PG (r=0.56, p-value<0.001). Sensitivity, specificity, PPV, NPV for HbA1c at cutoff of 6.5% in diagnosing diabetes mellitus (DM) were 70%, 89%, 72% and 80% respectively. Conclusion: High median HbA1c levels is noted in our subjects. At cut off level of HbA1c ≥6.5%, 70% of subjects with DM were diagnosed using ADA criteria of 2-h PG for diabetes as gold standard. Ethnic differences were also observed in levels of HbA1c. There is a need to define cut off for our population.
format	article
author	Aysha Habib Khan Sheharbano Imran Saira Furqan Hafsa Majid Lena Jafri Najmul Islam
author_facet	Aysha Habib Khan Sheharbano Imran Saira Furqan Hafsa Majid Lena Jafri Najmul Islam
author_sort	Aysha Habib Khan
title	COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
title_short	COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
title_full	COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
title_fullStr	COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
title_full_unstemmed	COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION
title_sort	comparison of diagnostic accuracy of glycated hemoglobin (hba1c) and 2-hour post glucose for diabetes using american diabetic association (ada) cut offs in pakistani population
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/cd776638fb404e5db5a30ff639ecabd4
work_keys_str_mv	AT ayshahabibkhan comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation AT sheharbanoimran comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation AT sairafurqan comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation AT hafsamajid comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation AT lenajafri comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation AT najmulislam comparisonofdiagnosticaccuracyofglycatedhemoglobinhba1cand2hourpostglucosefordiabetesusingamericandiabeticassociationadacutoffsinpakistanipopulation
_version_	1718405928177369088

COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION

Ejemplares similares