The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis

Long noncoding RNA (LncRNA), a noncoding RNA over 200nt in length, can regulate glycolysis through metabolic pathways, glucose metabolizing enzymes, and epigenetic reprogramming. Upon viral infection, increased aerobic glycolysis providzes material and energy for viral replication. Mitochondrial ant...

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Autores principales:	Zhihua Ren, Yueru Yu, Chaoxi Chen, Dingyong Yang, Ting Ding, Ling Zhu, Junliang Deng, Zhiwen Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glycolysis lncRNA antivirus innate immunity RIG-I/MAVS Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cd77f931e0dc400aa7bf30eef7f5bcab
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spelling	oai:doaj.org-article:cd77f931e0dc400aa7bf30eef7f5bcab2021-12-01T19:13:28ZThe Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis1664-302X10.3389/fmicb.2021.807737https://doaj.org/article/cd77f931e0dc400aa7bf30eef7f5bcab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.807737/fullhttps://doaj.org/toc/1664-302XLong noncoding RNA (LncRNA), a noncoding RNA over 200nt in length, can regulate glycolysis through metabolic pathways, glucose metabolizing enzymes, and epigenetic reprogramming. Upon viral infection, increased aerobic glycolysis providzes material and energy for viral replication. Mitochondrial antiviral signaling protein (MAVS) is the only protein-specified downstream of retinoic acid-inducible gene I (RIG-I) that bridges the gap between antiviral immunity and glycolysis. MAVS binding to RIG-I inhibits MAVS binding to Hexokinase (HK2), thereby impairing glycolysis, while excess lactate production inhibits MAVS and the downstream antiviral immune response, facilitating viral replication. LncRNAs can also regulate antiviral innate immunity by interacting with RIG-I and downstream signaling pathways and by regulating the expression of interferons and interferon-stimulated genes (ISGs). Altogether, we summarize the relationship between glycolysis, antiviral immunity, and lncRNAs and propose that lncRNAs interact with glycolysis and antiviral pathways, providing a new perspective for the future treatment against virus infection, including SARS-CoV-2.Zhihua RenYueru YuChaoxi ChenDingyong YangTing DingLing ZhuJunliang DengZhiwen XuFrontiers Media S.A.articleglycolysislncRNAantivirusinnate immunityRIG-I/MAVSMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycolysis lncRNA antivirus innate immunity RIG-I/MAVS Microbiology QR1-502
spellingShingle	glycolysis lncRNA antivirus innate immunity RIG-I/MAVS Microbiology QR1-502 Zhihua Ren Yueru Yu Chaoxi Chen Dingyong Yang Ting Ding Ling Zhu Junliang Deng Zhiwen Xu The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
description	Long noncoding RNA (LncRNA), a noncoding RNA over 200nt in length, can regulate glycolysis through metabolic pathways, glucose metabolizing enzymes, and epigenetic reprogramming. Upon viral infection, increased aerobic glycolysis providzes material and energy for viral replication. Mitochondrial antiviral signaling protein (MAVS) is the only protein-specified downstream of retinoic acid-inducible gene I (RIG-I) that bridges the gap between antiviral immunity and glycolysis. MAVS binding to RIG-I inhibits MAVS binding to Hexokinase (HK2), thereby impairing glycolysis, while excess lactate production inhibits MAVS and the downstream antiviral immune response, facilitating viral replication. LncRNAs can also regulate antiviral innate immunity by interacting with RIG-I and downstream signaling pathways and by regulating the expression of interferons and interferon-stimulated genes (ISGs). Altogether, we summarize the relationship between glycolysis, antiviral immunity, and lncRNAs and propose that lncRNAs interact with glycolysis and antiviral pathways, providing a new perspective for the future treatment against virus infection, including SARS-CoV-2.
format	article
author	Zhihua Ren Yueru Yu Chaoxi Chen Dingyong Yang Ting Ding Ling Zhu Junliang Deng Zhiwen Xu
author_facet	Zhihua Ren Yueru Yu Chaoxi Chen Dingyong Yang Ting Ding Ling Zhu Junliang Deng Zhiwen Xu
author_sort	Zhihua Ren
title	The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
title_short	The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
title_full	The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
title_fullStr	The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
title_full_unstemmed	The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis
title_sort	triangle relationship between long noncoding rna, rig-i-like receptor signaling pathway, and glycolysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cd77f931e0dc400aa7bf30eef7f5bcab
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The Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis

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