A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.

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Autores principales: Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo, Yoshinori Imai, Megumi Narukawa, Hidehisa Iwata, Tatsuyuki Matsudaira, Shimpei Kawamoto, Naoko Ohtani, Tamotsu Yoshimori, Eiji Hara
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cd78cc2a032e468c95cf625f4e739929
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spelling oai:doaj.org-article:cd78cc2a032e468c95cf625f4e7399292021-12-02T17:31:56ZA BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells10.1038/s41467-020-15719-62041-1723https://doaj.org/article/cd78cc2a032e468c95cf625f4e7399292020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15719-6https://doaj.org/toc/2041-1723Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.Masahiro WakitaAkiko TakahashiOsamu SanoTze Mun LooYoshinori ImaiMegumi NarukawaHidehisa IwataTatsuyuki MatsudairaShimpei KawamotoNaoko OhtaniTamotsu YoshimoriEiji HaraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Masahiro Wakita
Akiko Takahashi
Osamu Sano
Tze Mun Loo
Yoshinori Imai
Megumi Narukawa
Hidehisa Iwata
Tatsuyuki Matsudaira
Shimpei Kawamoto
Naoko Ohtani
Tamotsu Yoshimori
Eiji Hara
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
description Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.
format article
author Masahiro Wakita
Akiko Takahashi
Osamu Sano
Tze Mun Loo
Yoshinori Imai
Megumi Narukawa
Hidehisa Iwata
Tatsuyuki Matsudaira
Shimpei Kawamoto
Naoko Ohtani
Tamotsu Yoshimori
Eiji Hara
author_facet Masahiro Wakita
Akiko Takahashi
Osamu Sano
Tze Mun Loo
Yoshinori Imai
Megumi Narukawa
Hidehisa Iwata
Tatsuyuki Matsudaira
Shimpei Kawamoto
Naoko Ohtani
Tamotsu Yoshimori
Eiji Hara
author_sort Masahiro Wakita
title A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
title_short A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
title_full A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
title_fullStr A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
title_full_unstemmed A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
title_sort bet family protein degrader provokes senolysis by targeting nhej and autophagy in senescent cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cd78cc2a032e468c95cf625f4e739929
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